KF/K_2CO_3/γ-Al_2O_3催化合成反式阿魏酸的研究  

Study on the Catalytic Synthesis of Trans-ferulic Acid by KF/K_2CO_3/γ-Al_2O_3

作　　者：丁元生[1] 罗志臣[2] 

机构地区：[1]吉林化工学院化学与制药工程学院,吉林吉林132022 [2]扬州工业职业技术学院化学工程系,江苏扬州225127

出　　处：《安徽农业科学》2012年第27期13328-13329,13333,共3页Journal of Anhui Agricultural Sciences

基　　金：吉林省教育厅自然科学基金资助项目(2008174)

摘　　要：[目的]对KF/K2CO3/γ-Al2O3催化合成反式阿魏酸进行研究。[方法]以香兰素和丙二酸为原料,KF/K2CO3/γ-Al2O3为催化剂,经Knoevenagel缩合反应催化合成反式阿魏酸,考察反应时间、香兰素与丙二酸物质的量之比和催化剂用量等条件对反式阿魏酸收率的影响。[结果]催化合成的最佳工艺条件为:香兰素7.6 g(0.05 mol),n(香兰素)∶n(丙二酸)=1∶1.20,KF/K2CO3/γ-Al2O31.00 g,乙酸正丁酯25 ml,反应时间2 h;在此条件下,产品收率达到65%以上,且催化剂可以重复使用6次,收率依然超过60%。[结论]KF/K2CO3/γ-Al2O3具有良好的催化活性。[Objective] To study the catalytic synthesis of trans-ferulic acid by KF/K2CO3/γ-Al2O3 from vanillin and malonic acid using KF/Al2O3 as a catalyst.[Method] The trans-ferulic acid was catalytically synthesized from vanillin and malonic acid using KF/K2CO3/γ-Al2O3 as a catalyst by Knoevenagel condensation reaction.The factors influencing the yield of trans-ferulic acid was investigated,including reaction time,monomer ratio of vanillin to malonic acid and catalyst dosage.[Result] The optimum conditions for catalytic synthesis were found as follows： 7.6 g（0.05 mol）vanillin,n（Vanillin）∶n（malonic acid） = 1∶1.20,1.00 g KF/K2CO3/γ-Al2O3,25 ml n-Butyl acetate,and 2 h reaction time.The yield of trans-ferulic acid was above 65 %,and catalyst was used for 6 recycles,the yield of trans-ferulic acid was still above 60 %.[Conclusion] KF/K2CO3/γ-Al2O3 has good catalytic activity.

关 键 词：KF/K2CO3/γ-Al2O3 反式阿魏酸 KNOEVENAGEL缩合反应 催化 合成 

分 类 号：S567[农业科学—中草药栽培]