自噬与肺部疾病研究进展  

Research Progress of Autophagy and Pulmonary Diseases

作　　者：杨莉[1] 肖凌[1] 陈临溪[1] 

机构地区：[1]南华大学药物药理研究所,衡阳421001

出　　处：《生物化学与生物物理进展》2012年第9期861-868,共8页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金资助项目(30901577)~~

摘　　要：自噬(autophagy)是广泛存在于真核细胞中的基本生命现象,是细胞适应环境变化、防御病原微生物侵袭、维持内环境稳定的重要机制.多种肺部疾病中存在自噬活性的变化,自噬与肺部疾病的发生、发展密切相关.自噬在慢性阻塞性肺病、肺气肿、肺癌、肺结核等许多肺部疾病中发生,且发挥重要作用.现从自噬与多种肺部疾病的关系角度进行综述,有助于了解自噬在肺部疾病中发挥的作用,以便进一步研究自噬的调节,为肺部疾病的治疗提供新思路.Autophagy wildly exists in eucaryotic cells which is essential vital phenomena.Autophagy is an important mechanism that makes cells adapting the environment change, defensing invasion of pathogenic microorganism and maintaining homeostasis. The activity of autophagy fluctuates in many lung diseases, it closely related with the lung diseases＇ occurrences and developments. Autophagy has happened in pulmonary emphysema, chronic obstructive pulmonary disease, lung cancer, pulmonary tuberculosis and many other lung diseases, and plays an important role in these diseases. This review summarized it from the perspective of relationship of autophagy and lung diseases. It helps to understand the effect that autophagy produced in lung diseases and so as to further study the regulation of autophagy and to provide new ideas for the therapy of lung diseases.

关 键 词：自噬 慢性阻塞性肺病 肺气肿 肺癌 肺结核 肺动脉高压 

分 类 号：R56[医药卫生—呼吸系统] R363[医药卫生—内科学]