妇科腹腔镜术对血浆P-选择素、D-二聚体及vWF的影响  

Effect of Laparoscopy on P-Selectin, D-Dimer and von Willebrand Factor

作　　者：张锐[1] 黄浩[1] 李莉芳[1] 赵学峰[1] 王小婕[1] 刘瑾[1] 

机构地区：[1]南方医科大学附属南海医院,广东佛山528200

出　　处：《临床医学工程》2012年第9期1449-1450,1453,共3页Clinical Medicine & Engineering

基　　金：佛山市医学类科技攻关项目(编号:201108122)

摘　　要：目的观察妇科腹腔镜手术对患者血浆P-选择素、D-二聚体及vWF的影响,评估腹腔镜手术是否存在深静脉血栓的高危因素。方法选择腹腔镜及开腹卵巢囊肿切除各30例患者,术前及术后10min、术后24h检查血浆P-选择素、D-二聚体及vWF值,分析腹腔镜及开腹手术对上述指标的影响。结果两组术后血浆P-选择素、D-二聚体及vWF均有不同程度增高,与术前相比较有统计学意义(P<0.05),但腹腔镜组与开腹组在同期相比各指标差异无统计学意义(P>0.05)。结论腹腔镜手术可导致血浆P-选择素、D-二聚体及vWF值升高,有引起DVT风险;腹腔镜术对血浆P-选择素、D-二聚体及vWF产生的影响与开腹手术相当。Objective To investigate the influence of gynaecological laparoscopy operation on P-selectin, D-dimer and von Willeband factor （vWF）, and evaluate the risk factors of lower limb deep venous thrombosis （LDVT）. Methods 60 patients were randomized into laparoscopic resection group （30 cases） and open abdominal incision group （30 cases）. P-selectin, D-dimer and vWF were detected at preoperation, postoperative 10 min and 24 h in the two groups. Results P-selectin, D-dimer and vWF all significantly increased after operation in both groups compared with those before operation with statistically significant difference （P 〈0.05）, but without statistical difference at the same period between two groups. Conclusions P-selectin, D-dimer and vWF are increased by gynaecological laparoscopy operation which can raise the risk of venous thrombosis, but the risk has no difference compared with open abdominal incision operation.

关 键 词：腹腔镜 卵巢囊肿 深静脉血栓 P-选择素 D-二聚体 血管性血友病因子 

分 类 号：R713.6[医药卫生—妇产科学] R446.113[医药卫生—临床医学]