医用硫酸钙人工骨与同种异体骨修复良性骨肿瘤骨缺损的对比分析  

Calcium sulfate bone graft versus allograft bone in the treatment of benign bone tumors

作　　者：杨二平[1] 彭昊[1] 胡冰[2] 程子林[2] 徐宁路[2] 

机构地区：[1]武汉大学人民医院骨科,湖北省武汉市430064 [2]武汉科技大学附属天佑医院骨科,湖北省武汉市430064

出　　处：《中国组织工程研究》2012年第34期6293-6297,共5页Chinese Journal of Tissue Engineering Research

摘　　要：背景:探讨医用硫酸钙人工骨可替代同种异体骨作为骨缺损的修复材料的可行性。目的:观察医用硫酸钙人工骨材料治疗良性骨肿瘤骨缺损的临床疗效。方法:纳入应用医用硫酸钙人工骨材料于临床修复良性骨肿瘤刮除术后骨缺损病例31例和同种异体骨材料修复病例36例。观察植入材料后4,8,12周摄X射线片植骨吸收情况及植骨材料降解率。结果与结论:全部病例均获随访3个月以上。两组病例在随访期间植骨材料降解率差异无显著性意义。良性骨肿瘤植骨区无复发。患者植入材料后3个月X射线片示骨缺损部位有新骨生成。结果表明医用硫酸钙人工骨材料临床疗效和同种异体骨接近。BACKGROUND： We investigate the feasibility of calcium sulfate bone graft instead of allograft bone as a repair material for bone defects. OBJECTIVE： To observe the clinical effects of calcium sulfate bone graft on bone defects. METHODS： Totally 67 patients with bone defects receiving calcium sulfate bone graft （n=31） and allograft bone （n=36） were enrolled. At 4, 8; 12 weeks after implantation, the bone resorption and biodegradation of bone graft were calculated based on X-ray films. RESULTS AND CONCLUSION： The follow-up time was from 3 to 36 months with an average of 18 months. During the follow-up, there was no statistical difference in the degradation rate between the two groups. No benign bone tumor recurred in the bone graft area. X-ray films showed that new callus formed in the bone defect area at 3 months after implantation. These findings indicate that the calcium sulfate bone graft has a similar clinical effect to allograft bone.

关 键 词：硫酸钙 人工骨 材料 植骨 骨缺损 骨肿瘤 

分 类 号：R318[医药卫生—生物医学工程]