钛板在胸骨肿瘤胸骨切除治疗中的运用  

Application of titanium plates in sternal tumor resection

作　　者：虞桂平[1] 黄斌[1] 

机构地区：[1]东南大学医学院附属江阴医院胸心血管外科,江苏省江阴市214400

出　　处：《中国组织工程研究》2012年第34期6431-6434,共4页Chinese Journal of Tissue Engineering Research

摘　　要：背景:胸骨肿瘤一旦扩大切除,会导致巨大胸骨壁缺损,若不进行修复,正常胸廓的稳定性和胸腔的密闭性不能保持,常会引起严重的反常呼吸运动。组织工程材料在胸骨肿瘤中的应用是现在的研究热点。目的:探讨探讨组织工程学用于胸骨切除后胸廓重建的方法和临床效果,综述其修复过程中组织工程化材料的研究成果。方法:应用计算机检索1990-01/2011-02PubMed数据库及维普数据库有关组织工程学在胸骨切除术后胸廓重建中的应用的生物力学分析、组织工程材料在胸骨重建中应用及胸骨肿瘤扩大切除术后组织材料在其中的应用的相关文献,英文检索词"stemaltumors,reconstruction",中文检索为"胸骨肿瘤,胸廓重建,钛板",检索文献量总计100篇。结果与结论:目前胸廓重建材料分为生物材料和人工材料两大类,包括自体移植的骨、心包、筋膜和异体的牛筋膜、心包等。钛板能够保证有效手术后胸廓的稳定性,并且钛板具有不易发生排异反应,可在体内长期存留,便于消毒灭菌,不影响CT检查,便于塑型及固定,方便、安全性高,而且修复、整形的效果好,但长期疗效仍有待进一步观察。BACKGROUND：Sternal tumors extension and resection will lead to huge sternum wall defects,if not repair,the normal thoracic stability and the airtightness cannot be maintained,and often cause serious abnormal respiratory movement.The application of tissue engineering material in sternal tumors is the focus of the research now.OBJECTIVE：To investigate the method and the clinical application of tissue engineering in thoracic reconstruction after sternal tumors resection,and to summarize the research process of tissue engineering material.METHODS：A computer-based search was performed on PubMed database and VIP database from January 1990 to February 2011 for the related literatures with the Key words of ＂stemal tumors,reconstruction＂ in English and ＂stemal tumors,reconstruction,titanium plate＂ in Chinese.The literatures that related to the biomechanics of tissue engineering applications in the thoracic reconstruction after sternal tumors resection and the application of tissue engineering materials in the thoracic reconstruction after sternal tumors resection were included.A total of 100 literatures were obtained.RESULTS AND CONCLUSION：The materials used for the thoracic reconstruction are divided into two major categories：biological materials and artificial materials,including autologous bone,pericardium,fascia and allogeneic bovine fascia,pericardium,etc.Titanium plate can maintain the post-operative thoracic stability effectively.Titanium plate also has many advantages,such as not prone to rejection,long-term retention in the body,easy to disinfect and sterilize without affecting the CT scan,facilitate to model and fix,convenient,safe,and perfect repair and shaping effect.But the long-term efficacy still need to be further observed.

关 键 词：胸廓重建 胸骨肿瘤 钛板 生物相容性 生物材料 

分 类 号：R318[医药卫生—生物医学工程]