后路椎弓根钉置入复合纳米人工骨植骨治疗胸腰椎骨折  

Posterior pedicle screw fixation combined with nanotechnology bone graft for the treatment of thoracolumbar fracture

作　　者：黄旗凯[1] 李明[1] 胡文[1] 

机构地区：[1]解放军第二军医大学长海医院骨科,上海市200433

出　　处：《中国组织工程研究》2012年第35期6550-6554,共5页Chinese Journal of Tissue Engineering Research

摘　　要：背景:纳米人工骨最大优点为具有骨诱导活性和优异的成骨性能并且可任意塑型,不良反应低。目的:观察后路固定结合伤椎椎弓根纳米人工骨植骨治疗胸腰椎骨折疗效。方法:48例胸腰椎骨折患者均在入院3d内行后路椎弓根系统固定结合伤椎植入纳米人工骨治疗,分析对比治疗前后Cobb角,伤椎前缘高度及随访植骨融合。结果与结论:所有病例均获得9个月以上随访。患者植入纳米人工骨后7d及末次随访时Cobb角及伤椎前缘高较术前均有显著改善(P<0.05),末次随访与植入纳米人工骨后7d上述指标比较差异无显著性意义(P>0.05),所有病例植骨均愈合良好。结果表明,后路椎弓根螺钉系统固定结合伤椎纳米人工骨植骨治疗胸腰椎骨折对维持重建脊柱稳定性及维持矫正率效果好,植骨融合率高,愈合快。BACKGROUND： Nanotechnology bone has the advantages of osteoinductive activity and excellent osteogenic property, and it can be shaping with less adverse reactions. OBJECTIVE： To observe the effect of posterior pedicle screw fixation combined with nanotechnology bone graft on the treatment of thoracolumbar fractures. METHODS： Forty-eight thoracolumbar fracture patients were treated with posterior pedicle screw fixation combined with nanotechnology bone graft within 3 days after in hospital, the Cobb angel, the anterior vertebral height and bone healing before and after treatment were analyzed and compared. RESULTS AND CONCLUSION： All patients were followed-up for over 9 months. At 7 days after nanotechnology bone implantation and the last follow-up, the Cobb angel and the anterior vertebral height were significantly improved compared with the pre-operation （P 0.05）, while there was no significant difference of the indexes （P 0.05）. All injured vertebral bone was healed well. For the treatment of thoracolumbar fractures, posterior pedicle screw fixation combined with nanotechnology bone graft has a good effect in maintaining the stability and the correction efficiency of reconstructed spine with high fusion rate and short healing time.

关 键 词：纳米人工骨 胸腰椎骨折 内固定 COBB角 植骨融合 

分 类 号：R318[医药卫生—生物医学工程]