超声检测早期糖尿病肾病患者颈动脉内中膜厚度与血清金属蛋白酶组织抑制因子-1的相关性研究  

The Correlation between Intima-media Thickness in Common Carotid Artery and the Serum Levels of Tissue Inhibitor of Metalloproteinase-1 of Patients with Early Diabetic Nephropathy

作　　者：范玉龙 

机构地区：[1]山东省平阴县中医医院超声科,山东平阴250400

出　　处：《中国医药指南》2012年第23期426-427,共2页Guide of China Medicine

摘　　要：目的探讨超声检测早期糖尿病肾病患者颈动脉内中膜厚度(IMT)与血清金属蛋白酶组织抑制因子-1(TIMP-1)的相关性研究。方法选取60例早期糖尿病肾病患者作为观察组,30例无肾病并发症的糖尿病患者作为对照组;采用超声分别检测所有患者的颈动脉IMT,并检测观察组患者的血清TIMP-1。结果观察组IMP为(1.36±0.62)mm,对照组为(1.03±0.51)mm,两组之间有显著性差异(P<0.05);血清TIMP-1为(1506±193.5)ng/mL,与IMT比较正相关关系,r=0.049,P<0.05。结论超声检测颈动脉IMT可以为早期糖尿病肾病的诊断提供线索。Objective To study the correlation between intima-media thickness（IMT） in common carotid artery and the serum levels of tissue inhibitor of meta-lloproteinase-1 （TIMP-1） of patients with early diabetic nephropathy. Methods Sixty patients with early diabetic nephropathy were enrolled into the observation group and thirty patients without diabetic nephopathy were enrolled into the control group. The IMT in common carotid artery were detected through ultrasound. The TIMP-1 in the serum of patients with early diabetic nephropathy were examinated. Results The IMT of common carotid artery were respectively （1.36±0.62） mm in the observation group and （ 1.03±0.51 ） mm in the control group.There was significant difference between them（P〈0.05）. The concentration of TIMP-1 was （1506±193.5） ng/mL which has a positive correlation between it and IMT of common carotid artery（r=0.049, P〈0.05）. Conclusions The IMT of common carotid artery through ultrasound could make an important clue for the diagnosis of the early diabetic nephropathy.

关 键 词：早期糖尿病肾病 颈动脉内中膜厚度 金属蛋白酶组织抑制因子-1 

分 类 号：R587.2[医药卫生—内分泌]