先天性心脏病右心房心肌细胞超微结构改变的观察  

ULTRASTRUCTURAL OBSERVATIONS ON RIGHT ATRIAL CARDIAC MUSCLE CELLS OF PATIENTS WITH CONGENITAL HEART DISEASE

作　　者：廖晓岗[1] 李维信[1] 房秀生[2] 陈敦敏[2] 

机构地区：[1]重庆医科大学电镜宝 [2]重庆医科大学第一医院麻醉科

出　　处：《重庆医科大学学报》1990年第3期182-186,共5页Journal of Chongqing Medical University

摘　　要：有关先天性心脏病(简称先心病)心房肌超微结构改变尚未见有报导。本文对15例先心病右心房心肌进行了电镜观察。各例中除见少量正常肌细胞外,多数肌细胞均有肥大改变:细胞直径及核增大,线粒体增生,肌原纤维增加,T小管增多,出现多间盘等。部分肌细胞呈现退变,可见肌丝溶解,Z线异常,肌质网增多扩大,线粒体肿胀甚至外膜破裂,较多髓样结构,异常连接及间质纤维化等。结果提示心房肌肥大退变的程度似与先心病的类型。The ultrastructural changes in atrial cardiac muscle cells of congenital heart disease have, so far,not been reported. This study was concerned with the ultrastructural alterations of right atrial myocardium resected at operation from 15 patients with congenital heart disease. Excepting a small amount of atrial cardiac muscle cells which Seem to be normal, the most muscle cells were hypertrophied and degenerated in all 15 patients. The hypertrophic atrial cardiac muscle cells showed cell diamelers>20m, hypertrophy of nuclei, dilatation of T tubules, mutiple intercalated discs and increase of mitochondria and myofibrils. But the atrial cardiac muscle cells with degeneration showed myofibrillar lysis, abnormal Z bands, mitochondrial swelling and extramembranous disruption, sarcoplasmic reticulum proliferation and dilatation,myelin figures formation and interstitial fibrosis These results suggested that the degree of hypertropy and degeneration of atrial cardiac muscle cells was related to the types, injuried size of congenital heart disease and the age, cardiac functional state of patients

关 键 词：先天性心脏病 心房肌 超微结构 

分 类 号：R541.102[医药卫生—心血管疾病]