EsA对BXSB狼疮性肾炎小鼠作用观察  

Effect of Esculentoside A on therapeutic and cytokines secretion of lupus nephritis in BXSB mice

作　　者：马华林 张祥贵[2] 张欣洲 徐莹 

机构地区：[1]暨南大学第二临床医学院/深圳市人民医院肾内科,广东深圳518020 [2]遵义医学院第五附属医院肾内科,广东珠海519100 [3]广东省佛山市禅城区中心医院康复科,528031

出　　处：《重庆医学》2012年第28期2954-2955,2958,I0002,共4页Chongqing medicine

基　　金：遵义医学院珠海校区校区科研启动基金资助项目(KY200607)

摘　　要：目的观察商陆皂苷甲(EsA)对BXSB小鼠狼疮性肾炎(LN)的治疗作用及IL-6及TNF-α分泌的影响,探讨EsA对LN的可能作用机制。方法 12周龄雄性BXSB小鼠24只,随机分成模型对照组、EsA低剂量治疗组和EsA高剂量治疗组。腹腔注射每日1次,4周后达治疗终点。结果 EsA能显著降低BXSB小鼠尿蛋白/尿肌酐比值,改善BXSB肾脏病变。结论 EsA对BXSB狼疮性肾炎小鼠具有显著治疗作用,抑制IL-6及TNF-α分泌产生可能参与EsA抗炎机制。Objective To investigate the effect of Esculentoside A（EsA） on therapeutic and cytokines secretion in BXSB mice and the possible mechanism of EsA in treating lupus nephritis（LN）. Methods 24 male BXSB mice at the age of 12 weeks were ran- domly divided into 3 groups., untreated model group, EsA（5 mg ·kg^-1 . d^-1 ）-treated model group and EsA（20mg · kg · d^-1 ） treated model group. All mice at the age of 16 weeks were killed to obtain samples. Results EsA administration markedly alleviated urine protein/urine creatinine,improved pathological kidney damage and reduced the serum IL-6 and TNF-α level. Conclusion EsA may play significant roles in the treatment of BXSB mice through modulation on inflammatory cytokines.

关 键 词：商陆皂苷甲 狼疮肾炎 白细胞介素6 肿瘤坏死因子α BXSB小鼠 

分 类 号：R593.242[医药卫生—内科学]