糖尿病并脑梗死患者血清同型半胱氨酸水平及前列地尔治疗对其影响  

Serum Homocysteine Level in Patients with Diabetes Mellitus Combined with Cerebral Infarction and Influence by Prostaglandin E1 Injection Treatment

作　　者：于建敏[1] 孔祥瑞[2] 丁修冬[3] 耿纪录[1] 唐静怡[4] 

机构地区：[1]解放军309医院门诊部,北京100091 [2]解放军309医院移植研究所,北京100091 [3]解放军309医院检验科,北京100091 [4]解放军白求恩国际和平医院干部病房二科,石家庄050082

出　　处：《临床误诊误治》2012年第9期86-88,共3页Clinical Misdiagnosis & Mistherapy

基　　金：国家自然科学基金资助项目(31170764)

摘　　要：目的了解糖尿病并脑梗死患者血清同型半胱氨酸(homocysteine,Hcy)水平及前列地尔治疗对其影响。方法收集2010年7月—2011年7月来我院门诊就诊的糖尿病并恢复期脑梗死47例,均予前列地尔注射液治疗2周,治疗前后测定空腹血糖和血清Hcy水平并进行比较。结果糖尿病并脑梗死患者血清Hcy水平明显升高,高Hcy血症的发生率为72.3%。予前列地尔注射液治疗2周后,血清Hcy水平明显下降,与治疗前比较差异有统计学意义(P<0.01);脑梗死治疗总有效率为91.5%。结论糖尿病并恢复期脑梗死患者血清Hcy水平明显升高,前列地尔可通过降低血清Hcy水平有效改善脑梗死症状。Objective To investigate serum homocysteine level in patients with diabetes mellitus combined with cerebral infarction and influence by prostaglandin E1 injection treatment. Methods 47 patients with diabetes mellitus combined with cerebral infarction admitted during July 2010 and July 2011 were enrolled, and all the patients were given prostaglandin E1 injection treatment for two weeks. Blood glucose and serum homocysteine levels were measured and compared at the baseline and after treatment. Results Serum homocysteine level in patients with diabetes mellitus combined with cerebral infarction was significantly elevated, and the incidence rate of hyper-homocysteine was 72.3%. After prostaglandin E1 injection treatment for two weeks, serum homocysteine level decreased significantly （P 〈 0.01 ）, and the total efficacy rate in cerebral infarction patients was 91.5%. Conclusion Patients with diabetes mellitus combined with cerebral infarction may have high level of serum homocysteine, and prostaglandin E1 injection treatment may have curative effect in cerebral infarction by lowering serum homocysteine level.

关 键 词：糖尿病 脑梗死 同型半胱氨酸 前列地尔注射液 

分 类 号：R587.1[医药卫生—内分泌] R743.33[医药卫生—内科学]