慢性肺心病患者hs-CRP与NT-ProBNP的检测及临床意义  

Clinical significance of hs-CRP and NT-proBNP in patients with chronic pulmonary heart disease

作　　者：杨侠[1] 李雅莉[1] 冯向莉[1] 张洁[1] 李妙羡[2] 张进召[1] 张秋红[1] 

机构地区：[1]西安交通大学医学院第二附属医院呼吸内科,西安710004 [2]西安交通大学医学院第二附属医院临床检验科

出　　处：《陕西医学杂志》2012年第9期1223-1225,共3页Shaanxi Medical Journal

摘　　要：目的:探讨hs-CRP及NT-proBNP在慢性肺源性心脏病(PHD)中的变化及其意义。方法:将97例慢性阻塞性肺疾病(COPD)患者分为3组,检测单纯COPD组(A组28例)、COPD并发PHD代偿期组(B组36例)和COPD并发PHD失代偿期组(C组33例)hs-CRP及NT-proBNP值及COPD并发失代偿期PHD患者治疗后hs-CRP及NT–proBNP值。结果:3组患者hs-CRP及NT-proBNP值有极显著性差异(P<0.01),hs-CRP及NT-proBNP值为:C组>B组>A组。COPD并发失代偿期PHD患者治疗前与治疗后比较有极显著性差异(P<0.01)。结论:hs-CRP水平增高与PHD的发生、发展显著相关,对判断COPD患者病情及预后有指导意义。NT-proBNP浓度能较好反应COPD患者是否并发PHD及心功能状态。Objective：To study the change and the significance of hs-CRP and NT-proBNP in the patients with chronic pulmonary heart disease（PHD）. Methods： We recruited 97 patients in the same period after they re- ceived a diagnosis of COPD and divided them in to 3 groups. Group A contained 28 patients who had pure COPD. Group B contained 36 patients who had COPD, combined with chronic pulmonaryheart disease during compensatory stage. Group C contained 33 patients who had COPD combined with chronic pulmonary heart disease during decom pensatory stage. We measured hs-CRP and NT proBNP in plasma in these 97 patients and then analyzed the differ- ences of its level among the 3 groups. Results： There were significant differences among hs-CRP and NT-proBNP levels in plasma of the 3 groups （P〈0.01）. Each group of COPD patients hs-CRP, NT- proBNP serum level were： C group〉 B group〉 A group. After the therapy, the hs-CRP, NT-ProBNP serum levels significantly decreased with statistically differences （P〈0.01）. Conclusion： The increased hs-CRP levels are correlated with the occurring and developing of chronic pulmonary heart disease. The measurement of plasma NT-proBNP levels in patients with COPD can be used to identify whether they are combined with chronic pulmonary heart disease or heart insufficiency or not.

关 键 词：肺疾病 慢性阻塞性/并发症 肺心病/病因学 肺心病/血液 C反应蛋白质/代谢 @NT—ProBNP 

分 类 号：R541.5[医药卫生—心血管疾病]