通腑润肠汤治疗慢性功能性便秘的临床疗效研究  

Treatment Observation of Tongfu Renchang Decociton on Treating Chronic Functional Constipation

作　　者：杨勇军[1] 唐学贵[1] 李梅[2] 刘畅[1] 李钟艳[1] 吴至久[1] 何德才[1] 田小兵[3] 

机构地区：[1]川北医学院附属医院肛肠科,四川南充637000 [2]四川省中西医结合医院,四川成都610041 [3]川北医学院预防医学系,四川南充637000

出　　处：《四川中医》2012年第8期73-76,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察中药通腑润肠汤治疗慢性功能性便秘的临床疗效。方法:按功能性胃肠疾病罗马Ⅲ的诊治标准及排除标准选择符合研究条件的病例120例,随机分为两组,试验组用自拟通腑润肠汤的汤剂治疗60例,对照组用麻仁丸汤剂治疗60例。结果:试验组在每次排便时间、肛门阻塞感、用药后方能排便、短气、腹胀、大便性状和排便费力等症状改善方面与对照组比较更明显(P<0.05)。中药治疗便秘需要用药到一定的时间才显疗效。试验组60例中痊愈21例,显效19例,有效11例,无效8例,脱失1例,总有效率86.44%;对照组60例中痊愈10例,显效17例,有效12例,无效19例,脱失2例,总有效率67.24%。两组总有效率比较有显著性差异(P<0.05)。两组病例服药后均无实验室检查结果异常和不良事件发生。结论:通腑润肠汤治疗慢性功能性便秘具有临床疗效显著,安全性高,远期复发率低等优点。Objective： To study clinical effect of Tongfu Runchang Decoction for treating chronic functional constipation. Methods： According to the Rome Ⅲ standard of diagnosis, treatment and exclusion criteria for functional gastrointestinal disor- ders, 120patients with confirmed diagnosis of chronic functional constipation were randomly assigned to 2groups in single-blind way. The 60patients in experimental group were treated with Tongfu Runchang Decoction, while the other 60patients in control group were treated with Maren Pill. Results： Compared with control group, symptoms such as each defecate time, the feeling of anus obstruction, shortness of breath, abdominal distention, change of the defecate characters, defecate arduous and so on are improved more apparently in experimental group （P〈0. 05）. Chinese medicine treatment needs certain time to take significant effect. In experimental group, therapeutic effect assessment at the end of treatment showed that 21patients were cured, 19markedly effective, llimprovod, 8treated in vain and loft cases, while the 60patients in control group were treated with Maren Pill showed 10, 17, 12, 19and 2respectively. The total effective rate was 86. 44% in experimental group, while was 67. 24% in control group. There was significant difference in the comparison of the two groups （P〈0. 05）. No adverse event or abnormal test results occurred during the treatment course. Conclusion： Tongfu Runehang Decoction for treating chronic function- al constipation have significant clinical effect, high safety, low recurrence rate and has application value in primary hospitals.

关 键 词：慢性功能性便秘 临床研究 通腑润肠汤 

分 类 号：R256.35[医药卫生—中医内科学]