68例热性惊厥患儿临床特点及其血浆甘露糖结合凝集素水平变化  

Analysis of clinical characteristics and plasma level of mannose-binding lectin in 68 children with febrile convulsion

作　　者：王超前[1] 华春珍[1,2] 罗巧二 王琦婧[2] 戴凯丽[1] 黄邢邢[1] 杨钦梳[1] 

机构地区：[1]杭州师范大学临床医学院,浙江杭州310018 [2]杭州师范大学附属医院儿科,浙江杭州310015 [3]宁波妇女儿童医院,浙江宁波315012

出　　处：《中国儿童保健杂志》2012年第9期841-844,共4页Chinese Journal of Child Health Care

基　　金：浙江省新苗人才计划资助项目(2010R421034)

摘　　要：【目的】了解热性惊厥患儿的临床特点及其血浆甘露糖结合凝集素(mannose-binding lectin,MBL)水平在惊厥前后的变化。【方法】对2010年8月-2011年7月在本院住院的68例热性惊厥患儿,应用ELISA法检测急性期与恢复期血浆MBL浓度,同时进行临床特点分析。统计分析采用SPSS 11.0。【结果】急性期和恢复期MBL平均浓度分别为(595±559)ng/mL和(585±466)ng/mL,二者差异无统计学意义(Z=0.207,P=0.836),急性期与恢复期MBL水平呈线性相关(r=0.809,P<0.01)。其中恢复期MBL血浆浓度<200ng/mL的病例占29.4%,MBL参与急性应答占全部病例的38.2%。MBL浓度与CRP浓度无明显相关性(r=0.15,P=0.22)。89.7%的患儿热性惊厥由急性上呼吸道感染诱发,54.1%的患儿惊厥急性期CK-MB增高。【结论】惊厥应激对机体血浆MBL水平表达无明显影响。[Objective] To analyze the clinical characteristics of febrile convulsion （FC） occurred in children and study the mannose-binding lectin （MBL） levels in plasma at both acute and convalescent stages in the case group. [Methods] Plasma samples were separated from whole blood which was collected from children with FC at the acute and convalescent stages during August 2010 to July 2011. The MBL concentrations were measured by EI.ISA method and the SPSS 11.0 software was used in the study. [Results] Among all 68 cases,The mean MBL levels were （595±559）ng/mL at acute stage and （585±466）ng/mL in recovery stage,and no significant difference was found between the two groups （Z=0. 207,P= 0. 836）. However,there was a significant correlation of the MBL levels between the two stages （r= 0. 809, P〈0. 01）. 29.40/00 of all individuals had low MBL levels less than 200 ng/mL at convalescent stage. Acute reaction of MBL was ob served in 38.2% children with FC. No correlation was found between MBL levels and CRP levels（r =0.15,P=0.22）. It was found that 89.7 % of the FC children was caused by acute upper respiratory tract infection. The creatine kinase-MB exceeding normal value was found in 54. 1% of all individuals. [Conclusion] As a whole, convulsion acting as a kind of stress, had no significant effects on the MBL level in vivo.

关 键 词：热性惊厥 甘露糖结合凝集素 血浆浓度 临床特点 儿童 

分 类 号：R722[医药卫生—儿科]