不同甲状旁腺激素水平对维持性血液透析患者心肌损伤的影响  

The effect of different levels of parathyroid hormone on myocardial damage in maintenance hemodialysis patients

作　　者：宋素珍[1] 闵群燕[1] 胡永玮[1] 

机构地区：[1]江苏省太仓市第一人民医院肾内科,215400

出　　处：《国际移植与血液净化杂志》2012年第5期30-32,共3页International Journal of Transplantation and Hemopurification

摘　　要：目的探讨不同水平的甲状旁腺激素对慢性肾功能衰竭维持性血液透析患者心肌损伤的影响。方法将慢性肾功能衰竭维持性血液透析患者中血甲状旁腺激素〉300ng/L的42例患者作为高甲状旁腺激素组；将血甲状旁腺激素〈150ng/L的36例患者作为低甲状旁腺激素组，在血液透析前检测两组患者的血肌酐、尿素氮、血浆白蛋白、血红蛋白、血钙、血磷、钙磷乘积、全段甲状旁腺素及心肌肌钙蛋白I等指标进行对比观察。结果高甲状旁腺激素组患者血磷、钙磷乘积水平、心肌肌钙蛋白I与低甲状旁腺激素组患者比较差异有统计学意义（P〈0．05）。结论继发性甲状旁腺功能亢进与心肌损伤关系密切。Objective To explore the effect of different levels of parathyroid hormone （trFH） on myocardial damage in maintenacne hemodialysis （MHD） patients with chronic renal failure. Methods 78 maintenance hemodialysis patients with chronic renal failure was selected, blood of PYH 〉 300 ng/L, 42 cases were taken as a high PTH group; blood PTH 〈 150 ng/L, 36 cases as a low-PTH group. Before HD we examin their serum creatinine, blood urea nitrogen, serum albumin, hemoglobin, serum calcium, phosphorus, calcium-phosphorus product, intact parathyroid hormone （iPTH） and cardiac trponin I （cTn I ） and other indicators. Then compare the indicators of the two groups. Results The patients with high PTH-I group phosphorus, calcium-phosphate product levels, cardiac troponin I was significantly higher than the low PTH group. Conclusion Secondary hyperparathyroidism （SHPT） was closely associated with myocardial damage.

关 键 词：维持性血液透析 甲状旁腺激素 心肌损伤 

分 类 号：R692.5[医药卫生—泌尿科学]