玻璃酸钠联合曲安奈德治疗膝关节骨性关节炎  

The application of sodium hyaluronate combined with triamcinolone acetonide for osteoarthritis of knee joint

作　　者：杨博宇[1] 马一功[1] 朱银乐[1] 马峥[1] 王洪根[1] 

机构地区：[1]厦门市第二医院骨科,361021

出　　处：《中国医师进修杂志》2012年第26期26-29,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：目的比较玻璃酸钠与玻璃酸钠联合曲安奈德膝关节腔内注射治疗膝关节骨性关节炎（OA）的疗效。方法选取2010年3月至2011年3月接受膝关节腔内注射治疗的82例膝关节OA患者，以掷硬币法随机分为两组：单纯接受玻璃酸钠腔内注射42例（玻璃酸钠组），玻璃酸钠联合曲安奈德腔内注射40例（联合组）。两组均每周注射1次，共5次。疗效评价包括疼痛视觉模拟量表（VAS）测量值以及安全性评估。结果联合组在注射后1周上下楼梯时VAS测量值为（22．6±6．1）mm，较玻璃酸钠组的（63．9±5．8）mm显著降低，差异有统计学意义（P〈0．05）。联合组和玻璃酸钠组在疗程结束后3个月和6个月上下楼梯时VAS测量值比较差异无统计学意义[（42．2±6．6）mm比（41．1±5．3）mm，（48．5±5．5）mm比（49．3±6．2）mm]（P〉0．05）。两组治疗后膝关节功能皆优于治疗前，不良反应少见且轻微。结论玻璃酸钠与玻璃酸钠联合曲安奈德腔内注射都可以作为治疗膝关节OA的安全、有效的方法。玻璃酸钠联合应用曲安奈德可以提高治疗初期的疗效。Objective To compare the therapeutic effect of intraarticular injection with sodium hyaluronate （SH） and SH combined with triameinolone acetonide for osteoarthritis （OA） of knee joint. Methods Eighty-two patients with OA of knee joint were divided into two groups by toss a coin from March 2010 to March 2011. Forty-two patients simplely accepted SH injection （SH group）, 40 patients accepted SH combined with triamcinolone acetonide （combination group）. Intraarticular injection was taken once a week, a total of 5 times. Efficacy measurements included visual analog scale （VAS） for pain and safety. Results After treatment for 1 week, the measured value of VAS for up and down stairs in combination group was significantly lower than that in SH group[ （22.6 ~ 6.1 ）mm vs. （63.9 ~ 5.8 ） mm ] （P 〈 0.05 ）. After treatment for 3,6 months, the measured value of VAS for up and down stairs in two groups had no significant difference [（42.2 ±6.6） mm vs.（41.1 ±5.3） mm, （48.5 ±5.5） mm vs. （49.3 ±6.2） mm]（P〉0.05）. Function of the knee joint after treatment was better than before treatment in two groups. Adverse effects were minimal. Conclusions Intraarticular injection of SH and SH combined with triamcinolone aeetonide OA of knee joint is a safe and effective method. SH combined with triamcinolone acetonide can improve the efficacy in early period.

关 键 词：膝关节 透明质酸 糖皮质激素类 骨关节炎 

分 类 号：R684.3[医药卫生—骨科学]