白细胞介素18在老年糖尿病患者增强CT检查后的变化及意义  

Concentration of interleukin-18 in elderly type 2 diabetic patients underwent contrast-enhanced CT and its clinical significance

作　　者：王瑞强[1] 王毅[1] 蒲娟娟[1] 刘闯[1] 于洁[1] 李涛[1] 王瑞勇 

机构地区：[1]郑州大学第一附属医院老年病科,450052 [2]河南省高等学校临床医学重点学科开放实验室

出　　处：《中国实用医药》2012年第24期26-28,共3页China Practical Medicine

基　　金：国家自然科学基金(项目编号:20905065)

摘　　要：目的老年和糖尿病是造影剂肾病发生的高危因素,本试验的目的是观察老年糖尿病患者在增强CT检查后白细胞介素18(IL-18)的变化以及早期预测造影剂肾病的意义。方法选择2011年1月到2011年10月在我院接受增强CT检查的年龄大于60岁、糖尿病史1年以上、无明显肾功能异常的患者共30例,患者均采用低渗非离子型造影剂。ELISA法测定造影前和造影后24h、48hIL-18以及血尿素氮(BUN)、血肌酐(SCr)、血胱抑素C(CysC)。结果观察对象均无造影剂肾病的发生,造影后血IL-18与造影前比较无统计学意义(P>0.05),造影后24h尿IL-18、血胱抑素C升高明显,与造影前比较差异有统计学意义(P<0.05),48h后SCr升高明显(P<0.05),具有统计学意义。结论尿IL-18是可以早期反映肾损伤的敏感指标,对造影剂肾病的早期诊断及防治有重要作用。Objective Elderly and diabetes mellitus constitute to be high-risk factors for the development of contrast-induced nephropathy（CIN）.The aim of this study was to investigate the concentration of interleukin-18 after iohexol-enhanced computed tomography（CT） procedures.Methods 30 elderly diabetic patients without renal impairment who scheduled for contrast-enhanced CT were enrolled from January 2011 to October 2011 in our hospital.All patients were given low-osmolar nonionic contrast media.The concentration of interleukin-18 was measured with ELISA.Results There was no significant difference between the level of serum IL-18 adopted before contrast-enhanced CT and those adopted at the 24 and 48 hours after examination（P〉0.05）.The levels of urine IL-18 and serum cystatin C adopted at the 24 and 48 hours after contrast-enhanced CT significantly rose（P〈0.05） than that adopted before examination.The levels of serum creatinine rose at the 48 hours after contrast-enhanced CT（P〈0.05） than that adopted before examination.Conclusion The urine IL-18 is sensitive biological parameter for predicting kidney injury.So it can be clinically applied to monitor CIN.

关 键 词：白细胞介素18 糖尿病 造影剂肾病 

分 类 号：R446.1[医药卫生—诊断学]