CYP2D6基因多态性与抗精神病药物的个体化应用  

Genetic polymorphism of CYP2D6 and its influence on the personalized usage of antipsychotics

作　　者：陈冰[1] 蔡卫民[2] 杨婉花[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院药剂科,上海200025 [2]复旦大学药学院临床药学系,上海201203

出　　处：《中国临床药理学与治疗学》2012年第9期1067-1074,共8页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：CYP2D6是一种重要的细胞色素P450酶,存在着显著的基因多态性。CYP2D6在抗精神病类药物的代谢中发挥着重要作用,与许多抗精神病药物药动学及药效学的个体间变异存在着密切联系,检测CYP2D6基因型有助于患者抗精神病药物治疗方案的选择和调整,提高用药的安全性和有效性。本文综述CYP2D6基因多态性对抗精神病药物的药动学、不良反应及药物相互作用的影响,探讨了CYP2D6基因型检测在抗精神病个体化治疗中的应用前景。CYP2D6 is one of the most impor-tant cytochrome P450 enzymes. There is re-markable genetic polymorphism of CYP2D6. CYP2D6 play an important role in the metabo lism of antipsychotics, and has significant corre-lation with the inter-individual difference of pharmacokinetics and pharmacodynamics of anti-psychotics. Determination of CYP2D6 genotypes is helpful in the selection and regulation of antip-sychotic therapy regimen for the elevation of ef-ficiency and safety. The influence of CYP2D6 genetic polymorphism on the pharmacokinetics, adverse effect and drug-drug interaction was re-viewed and the usefulness of CYP2D6 genoty-ping in the personalized antipsychotic therapy was discussed.

关 键 词：CYP2D6 基因多态性 抗精神病药物 药动学 不良反应 

分 类 号：R969[医药卫生—药理学]