急性染镉对小鼠肝肾组织谷胱甘肽的影响  

Effects of Acute Cadmium Exposure on Glutathione Levels in Mice Livers and Kidneys

作　　者：周桂凤[1] 曾明[2] 钟才高[2] 高泽宣[2] 王夷平[2] 王安[2] 

机构地区：[1]湖南医学高等专科学校预防系,长沙410006 [2]湖南医科大学卫生毒理研究室

出　　处：《实用预防医学》2000年第2期98-99,共2页Practical Preventive Medicine

基　　金：湖南省教委科研基金立项资助!(湘教财字 [1 998] 1号;编号 :98B1 2 2 )

摘　　要：[目的 ]　探讨氯化镉急性染毒对小鼠肝脏、肾脏谷胱甘肽 (GSH )代谢的影响。 [方法 ]　给小鼠一次性腹腔注射不同剂量氯化镉 ,9小时后测定肝、肾组织镉、丙二醛 (MDA)、GSH含量。 [结果 ]　各剂量组肝、肾镉含量升高 ,高剂量组肝、肾MDA含量升高 ,肾GSH含量下降 ,肝脏GSH呈现先升高 ,后下降的剂量反应关系。 [结论 ]　氯化镉染毒 9小时后可同时在小鼠肝、肾脏蓄积 ,并引起肝肾脂质过氧化反应 ;小鼠肝、肾脏对急性镉染毒诱导的GSH代谢机理可能不同。Objective] To study the effects of acute cadmium chloride exposure on GSH metabolism in mice livers and kidneys.[Methods] Mice were given a single ipinjection of cadmium chloride in different dose and 9 hours later, Cd and GSH、MDA concentration in the livers and kidney were determined.[Result] The cadmium contents in livers and kidneys of all exposured mice increased. in the higher dose Cd-treated group, Renal and hepatic MDA significantly increased and renal GSH were lower than that of the control group. At the same time, hepatic GSH was first raised and declined afterwards with dose of CdCl 2 exposure increased.[Conclusion] Cadmium can be accumulated and induced lipid peroxidation reaction in mice livers and kidneys after 9 hours CdCl 2 exposure; GSH metabolism of cadmium inducement in mice livers and kidneys may be different.

关 键 词：镉 谷胱甘肽 丙二醛 肝 肾 

分 类 号：R992[医药卫生—毒理学] R995[医药卫生—药学]