宣痹通络汤对冠心病稳定型心绞痛患者血超氧化物歧化酶及丙二醛的影响  

Effect of Xuanbi Tongluo Decoction on Superoxide Dismutase and Malondialdehyde in Stable Angina Pectoris Patients

作　　者：潘力弢[1] 郑运英[1] 高林林[2] 

机构地区：[1]深圳市第二人民医院中医科,广东省深圳市振华路2号518081 [2]成都中医药大学

出　　处：《中医杂志》2012年第19期1658-1660,共3页Journal of Traditional Chinese Medicine

基　　金：深圳市科技计划项目资助(200903052)

摘　　要：目的探讨宣痹通络汤对稳定型心绞痛的临床疗效及抗自由基损伤、保护缺血心肌的作用。方法将124例稳定型心绞痛患者随机分为消心痛组41例,宣痹通络汤组40例,宣痹通络汤联合消心痛治疗组(联合用药组)43例。观察3组患者的心绞痛疗效,检测血中超氧化物歧化酶(SOD)和脂质过氧化物丙二醛(MDA)水平的变化,并与健康者35人(健康人组)比较。结果宣痹通络汤组总有效率85.00%,消心痛组为73.17%,联合用药组为88.37%,宣痹通络汤组和联合用药组心绞痛疗效与消心痛组比较差异有统计学意义(P<0.05),宣痹通络汤组和联合用药组心绞痛疗效差异无统计学意义(P>0.05)。治疗前各组患者SOD活性明显低于健康人组,而MDA水平明显高于健康人组(P<0.05)。治疗后宣痹通络汤组和联合用药组患者SOD活性明显升高、MDA水平明显下降(P<0.05),并且优于消心痛组(P<0.05)。消心痛组患者治疗后SOD活性、MDA水平与治疗前比较差异无统计学意义(P>0.05)。结论宣痹通络汤可有效改善稳定型心绞痛的发作,其机制可能与保护SOD活性、抑制MDA的产生有关。Objective To observe the therapeutic effect of Xuanbi Tongluo Decoction （decoction to diffise impediment and free the network vessels） on stable angina pectoris and its effect in anti-free radical damage and protecting the isehemie myoeardium. Methods Totally 124 cases of stable angina pectoris were randomized into isosorbide dinitrate （ISDN） group of 41 cases, Xuanbi Tongluo Decoction group of 40 cases and combo therapy group of 43 cases. The therapeutic effect and the levels of superoxide dismutase （SOD） and malondialdehyde （MDA） were observed before and after treatment and were compared with 35 healthy subjects. Results The total effective rate of the Xuanbi Tongluo Decoction group, the ISDN group, and the combo therapy group, was 85.00%, 73. 17% and 88.37% respectively. The total effective rates of the Xuanhi Tongluo group and combo therapy group was superior to that of the ISDN group （P〈0.05）. There was no significant difference in the total effective rate between Xuanbi Tongluo group and combo therapy group （P〉0.05）. Before treatment, the activity of SOD in angina patients was lower than that in the healthy （P〈0.05）, and the level of MDA in angina patients was higher than that in the healthy （P〈0.05）. The activity of SOD was significantly increased and the level of MDA was significantly decreased in the Xuanbi Tongluo Decoction group and the combo therapy group after treatment （P〈0.05）. There was no significant difference in the activity of SOD and level of MDA between before and after treatment in the ISDN group （P〉0.05）. Conclusion Xuanbi Tongluo Decoction could effectively relieve the attack of stable angina pectoris, which may be relevant to preventing SOD and inhibiting MDA.

关 键 词：宣痹通络汤 心绞痛 超氧化物歧化酶 丙二醛 

分 类 号：R259[医药卫生—中西医结合]