N-氯乙酰基-β-苯乙胺衍生物的合成及其表征  

Synthesis and Characterization of N-Chloro-Acetyl-β-Phenylethylamine Derivatives

作　　者：王宇[1] 曾庆东[1] 程鹏[1] 彭杨[1] 朱必敏[1] 余瑜[1] 

机构地区：[1]重庆医科大学药学院,重庆市渝中区医学院路1号400016

出　　处：《光谱实验室》2012年第5期2634-2638,共5页Chinese Journal of Spectroscopy Laboratory

基　　金：国家自然科学基金(30772595;30171070;30371632);重庆市科委攻关项目(20021425);重庆市教委项目(20021804)

摘　　要：建立了新化合物N-氯乙酰基-4-乙酰基-β-苯乙胺、4-[[(羟基)亚胺基]乙基]-N氯-乙酰基-β-苯乙胺和N-氯乙酰基-4-羟乙基-β-苯乙胺的合成方法,并且着重考察了N-氯乙酰基-4-乙酰基-β-苯乙胺的合成条件。结果表明,其合成的最适条件为:原料与三氯化铝的摩尔比为1∶3,原料与乙酰氯的摩尔比为1∶2,在20℃条件下滴加原料的二氯甲烷溶液,滴加完毕后反应体系控制在30℃,在此条件下反应,产物收率可达85%。产品结构通过IR、1H NM R、M S确证。The new methods of synthesis of N-chloroacetyl-4-acetyl-β-phenylethylamine,4-[[（hydroxyl） imino]ethyl]-N-chloroacetyl-β-phenylethylamine and N-chloroacetyl-4-hydroxyethyl-β-phenylethylamine were established.The synthetic conditions of N-chloroacetyl-4-acetyl-β-phenylethylamine were investigated.The optimum synthetic conditions were as follows：the mole ratio of raw material to aluminum chloride was 1∶3,the mole ratio of raw material to acetyl chloride was 1∶2,methylene chloride solution of raw material was added at 20 ℃,the temperature of the reaction system after dropping was 30℃.The yield can get 85% under the conditions.The structures of target compounds were characterized by IR,^1H NMR,MS.

关 键 词：N氯-乙酰基β-苯乙胺衍生物 合成 表征 

分 类 号：O657.33[理学—分析化学] O657.63[理学—化学]