独活寄生汤传统汤剂与其配方颗粒汤剂相关成分的对比分析  

Comparison Analysis of Compositions of Traditional Decoction and Dispensing Granule Decoction of Duhuo Jisheng Tang

作　　者：王爱武[1] 何慧[2] 王楠楠[1,3] 赫清雪[1,3] 

机构地区：[1]山东大学附属省立医院药剂科,济南250021 [2]山东省食品药品检验所,济南250101 [3]山东中医药大学药学院,济南250355

出　　处：《中国药学杂志》2012年第18期1469-1473,共5页Chinese Pharmaceutical Journal

基　　金：山东省中医药科技发展计划课题(2007-123)

摘　　要：目的对独活寄生汤传统汤剂与其配方颗粒汤剂组方药物的成分进行对比分析,探索二者内在质量的异同。方法采用薄层色谱法对独活寄生汤传统汤剂与其配方颗粒汤剂处方中的独活、桑寄生、当归、川芎、茯苓、白芍、秦艽、甘草8种饮片相关成分进行对比;采用高效液相色谱(HPLC)法对其中的有效成分芍药苷含量进行对比。结果薄层色谱显示传统饮片汤剂中8种饮片相关成分的斑点明显多于配方颗粒汤剂的斑点,传统汤剂中芍药苷含量为29.37 mg.g-1,同等比例配方颗粒中芍药苷含量为2.59 mg.g-1。结论独活寄生汤传统汤剂的成分含量高于配方颗粒汤剂,两者之间存在差异。OBJECTIVE To study and compare the compositions of traditional decoction and compatible granules of Duhuo Jish- eng Tang and reveal their differences in inner quality. METHODS The compositions of eight medicines, i. e. , duhuo, sangjisheng, danggui, chuangxiong, fuling, baishao, qinjiao and gancao in traditional decoction and dispensing granule decoction, were identified by TLC. And the contents of paeoniflorin were determined by HPLC. RESULTS There were more spots of the eight than dispensing granules. The content of peaoniflorin of the traditional decoction was 29. 37rag·g^-1 The content of peaoniflorin of the dispensing granule decoction is 2.59 mg·g^-1. CONCLUSION Composition contents in traditional decoction from Duhuo Jisheng Tang is high- er than that of dispensing granule decoction.

关 键 词：独活寄生汤 传统汤剂 配方颗粒 成分 薄层色谱法 高效液相色谱 芍药苷 

分 类 号：R917[医药卫生—药物分析学]