抗中性粒细胞胞浆抗体相关小血管炎研究进展  

Research advances in antineutrophil cytoplasmic antibody-associated vasculitis

作　　者：赵明辉[1] 

机构地区：[1]北京大学肾脏病研究所暨北京大学第一医院肾内科,北京100034

出　　处：《中国实用内科杂志》2012年第9期680-683,共4页Chinese Journal of Practical Internal Medicine

摘　　要：在中国,抗中性粒细胞胞浆抗体(ANCA)相关小血管炎主要为髓过氧化物酶(MPO)-ANCA阳性的显微镜下型多血管炎,好发于中老年,肾脏受累重。近年发现正常人血清中存在天然ANCA、PTU可诱发ANCA、补体旁路活化参与了发病机制。糖皮质激素联合环磷酰胺仍为一线诱导治疗方案。Myeloperoxidase-antineutrophil cytoplasmic antibody （MPO-ANCA） positive microscopic polyangitis the major category of ANCA-associated vasculitis in China and may be featured of marked renal involvement among the middle-aged and elderly. Recent studies have revealed that natural ANCA exist in normal individuals, propylthiouracil may induce ANCA and activation of complement alternative pathway is involved. The combination of eorticosteroid and cyclophosphamide remains to be the first-line regimen.

关 键 词：系统性血管炎 小血管炎 抗中性粒细胞胞浆抗体 肉芽肿性多血管炎 显微镜下型多血管炎 嗜酸细胞性肉芽肿性多血管炎 

分 类 号：R59[医药卫生—内科学]