复方丹参片薄层色谱鉴别方法研究  

Study on TLC identification for compound Danshen tablets

作　　者：吴笛[1] 王德勤[1] 李楚源[1] 

机构地区：[1]广州白云山和记黄埔中药有限公司现代中药研究院,广州510515

出　　处：《药物分析杂志》2012年第9期1658-1660,共3页Chinese Journal of Pharmaceutical Analysis

基　　金：国家"重大新药创制"科技重大专项(2011ZX09201-201-01)

摘　　要：目的:验证中国药典2010年版一部复方丹参片项下丹参酮ⅡA、冰片的薄层色谱鉴别方法,并加以改进,建立新的薄层色谱鉴别方法。方法:以二氢丹参酮Ⅰ、隐丹参酮、丹参酮Ⅰ、丹参酮ⅡA、冰片为指标性成分,按照中国药典方法及改进的方法,分别对复方丹参片进行薄层色谱鉴别。结果:改进的薄层色谱鉴别方法操作简便,准确,可靠,克服了药典方法的不足,可用于复方丹参片的质量控制。结论:中国药典2010年版一部复方丹参片项下丹参酮ⅡA、冰片的薄层色谱鉴别方法应及时修订,以保证检验结果的准确、可靠。Objective ： To verify the feasibility of Chinese Pharmacopoeia method of TLC identification for compound Danshen tablets and develop an improved method. Methods：TLC identification of dihydrotanshinone I , cryptotan- shinone, tanshinone I , tanshinone II A and borneol were carried out using Chinese Pharmacopoeia method and the improved method, respectively. Results： The improved method was proved to be simple, accurate, and reliable, which overcame the deficiencies of the Chinese Pharmacopoeia method, and can be used for the quality control of com- pound Danshen tablets. Conclusion：Chinese Pharmacopoeia method of TLC identification for compound Danshen tablets need to be promptly amended to ensure the accuracy and reliability of the assay.

关 键 词：复方丹参片 丹参酮 二氢丹参酮 隐丹参酮 冰片 薄层鉴别 标准改进 

分 类 号：R917[医药卫生—药物分析学]