X线照射对大鼠肾病的保护作用  

Protective role of sublethal X-irradiation on adriamycin-induced nephropathy in Wistar rats

作　　者：熊祖应[1] 乔孝儒[1] 丁长海[2] 梅俏[2] 徐叔云[2] 

机构地区：[1]安徽医科大学第一附属医院,合肥230022 [2]安徽医科大学临床药理研究所

出　　处：《中国校医》2000年第2期84-86,共3页Chinese Journal of School Doctor

摘　　要：目的 观察次和死量Ｘ线照射（ＸＩ）对大鼠阿霉肾病（ＡＩＮ）是否具有保护作用。方法 将大鼠分为ＸＩ、阿霉素和ＸＩ／ＡＤＲ组，检测各组大鼠０￣４周时尿蛋白排泄量（ＵＰＥ）、尿丙二醛排泄量（ＭＤＡ）和４周时血浆生化指标。结果 ＡＤＲ组大鼠呈典型的肾病综合征表现，ＸＩ／ＡＤＲ组大鼠外周血白细胞总数明显降低，ＵＰＥ减少，血浆总蛋白和白蛋白回升，血浆胆固醇和甘油三酯明显降低；同时。Objective To investigate whethar sublethal X-irradiation (Ⅺ) can retard renal injury of adriamycin-induced nephropathy(AN) .Methods As the second dsy in rats areived (Ⅺ),adriamycin (ADR) was intravenously administered at a single dose(5mg/kg)into femaleWistar rats to induce nephrosis and all animals were devided into 3 groups as group Ⅺ,ADR and (Ⅺ)/ADR. Urinary protein excretion (UPE) andmolondiadehyde (MDA) in urine at from 0 to 4 weeks,and biochemical parameters in plasma at 4th week were measured.Results All animals ingroup ADR developed a nephrotic syndrome characterized by heavy proteinuria, hypoalbuminemia, hypercholesterolemia, and ascites.Three was a significant deerease in circulating white blood cell count (WBC) after the rats received Ⅺ. UPE was remarkedly decreased in-group Ⅺ/ADR as compared with the in-group ADR. In contras to ADR,the level of MDA in urine was significantly declined. Conclusion These data showed that wholebody sublethal Ⅺ delivered during AIN is capable of preventing renal injury.

关 键 词：X线照射 阿霉素 肾病 肾病综合征 蛋白尿 丙二醛 

分 类 号：R692[医药卫生—泌尿科学]