天宝肿宁散醇提取物对不同细胞的生物学作用  

Studies on the Biological Effects of Alcohol Extraction of Tian Bao Zhong Ning San on Different cell lines

作　　者：周俊[1] 殷学军[1] 刘德祥[1] 仇东辉[1] 张月明[2] 闫浩[2] 

机构地区：[1]兰州军区乌鲁木齐总医院临床医学研究所,乌鲁木齐830000 [2]新疆医学院

出　　处：《浙江中西医结合杂志》2000年第5期260-263,共4页Zhejiang Journal of Integrated Traditional Chinese and Western Medicine

基　　金：新疆维吾尔自治区科委科研基金资助!项目编号:G9531008

摘　　要：目的 :观察“天宝肿宁散”方剂对小鼠成纤维细胞 ( 3T3)和人膀胱癌细胞 ( EJ)、人喉癌细胞( Hep- 2 )、人胃癌细胞 ( MGC- 80 3)、人肝癌细胞 ( Q3)以及人肺癌细胞 ( Spc- A- 1)等肿瘤细胞生物学作用。方法 :采用体外细胞培养法。结果 :显示该方剂具有抑制以上癌细胞的细胞增殖和蛋白质代谢 ,而且可致这些癌细胞的生长形态发生改变 ,但对小鼠 ( 3T3)细胞无明显抑制作用。结论Objective:To explore the biological effects of Tian Bao Zhong Ning San on different cell lines. Methods:Cell culture in vitro was used to investigate the effects of Chinese medicinal heabs Tian Bao Zhong Ning San on mouse fibroblast,bladder carcinoma cell lines (EJ),throat carcinoma cell lines (Hep2),stomach carcinoma cell lines (MGC803),hepatic carcinoma cell lines (Q3) and lung carcinoma cell lines (SpcA1). Results:The prescription proved to be effective in inhibiting the survival and protein metabolism of the cancer cells,inducing the morphalogical changes of the cultured cells. But no such effect was observed on mouse cell 3T3,suggesting that the prescription had different regulating effects on cancer cells and normal cells. Conclusion:Tian Bao Zhong Ning San had the effects of inhibiting growth of cancer cells.

关 键 词：天宝肿宁散 细胞 生物学作用 中药 药理 

分 类 号：R285[医药卫生—中药学]