肥胖与阻塞性睡眠呼吸暂停低通气综合征关系的研究进展  

Advances in relationship between obesity and obstructive sleep apnea-hypopnea syndrome

作　　者：黄晓波[1] 张锦[2] 

机构地区：[1]宁夏医科大学第二附属医院呼吸内科,银川750001 [2]宁夏医科大学总医院呼吸内科,银川750004

出　　处：《国际呼吸杂志》2012年第17期1345-1348,共4页International Journal of Respiration

摘　　要：肥胖与阻塞性睡眠呼吸暂停低通气综合征（OSAHS）存在部分共享的易感基因，两种疾病关系密切、互相影响。肥胖患者存在上气道形态功能异常、内脏脂肪积聚，从而导致OSAHS的发生；而OSAHS患者慢性缺氧，导致全身炎症反应、胰岛素抵抗、脂代谢紊乱等异常，又可加重肥胖。本文就肥胖与OSAHS关系的研究进展综述如下。Close relationship was observed between obesity and obstructive sleep apnea-hypopnea syndrome （OSAHS）, both of them shared some susceptible gene. Abnormal of upper airway and accumulation of visceral fat was frequently observed in obesity patients, which may lead to OSAHS. Chronic hypoxia in patients with OSAHS result in systemic inflammatory response, insulin resistance and lipid metabolism disorder, which may aggravate obesity conversely. This article is to introduce some advances in relationship between obesity and OSAHS.

关 键 词：肥胖 阻塞性睡眠呼吸暂停低通气综合征 发病机制 

分 类 号：R766[医药卫生—耳鼻咽喉科]