HGV-RNA阳性与阴性慢性乙型肝炎患者的对比研究  

A comparative study on HGV-RNA positive and negative patients with chronic hepatitis B

作　　者：商庆华[1] 于建国[1] 王磊 张光曙[1] 陈崇兴[1] 景敏 

机构地区：[1]解放军88医院济南军区肝病研究所,山东泰安271000 [2]安徽省临泉县人民医院 [3]山东省蒙阴县岱固医院

出　　处：《胃肠病学和肝病学杂志》2000年第1期48-49,53,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的　研究慢性乙型肝炎 (CHB)患者庚型肝炎病毒 (HGV)感染的意义。方法　应用RT -PCR法对 14 6例CHB患者血清进行了HGV -RNA检测 ,并将HGV -RNA阳性与阴性患者进行临床与病理学对比。结果　HGV -RNA阳性 2 3例 ( 15 .75 % )。HGV -RNA阳性与阴性患者肝功能等生化指标水平、肝脏病理损害程度、HBV -DNA阳性率均无显著性差异 (P <0 .0 5 )。 5例HGV -RNA阳性、16例HGV -RNA阴性CHB患者干扰素的近期疗效无显著差异 (P >0 .0 5 )。结论　CHBHGV感染并不加重肝脏损害 ,亦不影响HBV的复制及干扰素的疗效 ;Aim In order to study the significance of HGV infection in patients with chronic hepatitis B(CHB).Methods HGV-RNA were detected in serum samples from 146 patients with CHB by reverse transcription-polymerase chain reaction,the clinical and pathologic features of HGV-RNA positive patients were compared with those of HGV-RNA negative patients.Results Twenty three patients(15.75%) were positive for serum HGV-RNA,the rest were negtive.There were no significant differences in the level of liver function and other biochemical tests,HBV-DNA positive rate and the severity of liver pathologic lesions between the two groups(P>0.05).And same as in the short-term efficacy of interferon therapy to 5 HGV-RNA positive and 16 HGV-RNA negative patients (P>0.05). Conclusion HGV infection does not aggravate the liver lesions,HBV replication and response to interferon therapy of CHB.Pathogenicity of HGV is mild probably.

关 键 词：乙型肝炎 庚型肝炎病毒 RT-PCR 

分 类 号：R512.62[医药卫生—内科学]