人类基因组计划的倡导者——杜尔贝科  

Advocate of Human Genome Project——Renato Dulbecco

作　　者：郭晓强[1] 

机构地区：[1]中国人民解放军白求恩军医学院生化教研室

出　　处：《科学》2012年第5期40-43,4,共4页Science

摘　　要：癌症是严重威胁人类健康的重大疾病．目前对癌症机制的研究早已深入到分子水平．但中晚期癌症的治疗手段仍然有限，且远远无法达到人们的预期，因此对癌症的攻克仍然任重道远。进入21世纪，癌症的研究开始拓展到基因组层面，从而开拓了一个新的研究方向——癌症基因组学．而最早提出该想法的是意大利裔美国病毒学家、1975年诺贝尔生理学或医学奖获得者杜尔贝科（R．Dulbecco）。Renato Dulbecco was an Italian-born American virologist and shared the 1975 Nobel Prize in Physiology or Medicine for the discovery concerning the interaction between tumor viruses and the genetic materials in the cells.In the 1950s,Renato Dulbecco developed a practical method for studying animal viruses in cell cultures,known as plaque method,which was important in genetic studies of viruses.In the 1960s,Dulbecco demonstrated the mechanism of tumor transformation by oncogenic viruses such as polyomavirus,which insert its DNA into the DNA of the host cell.In 1986,Dulbecco published an influential paper in Science magazine that urged the sequencing of all human genes,starting the worldwide Human Genome Project.

关 键 词：杜尔贝科病毒致癌机制人类基因组计划诺贝尔生理学或医学奖 

分 类 号：R346[医药卫生—基础医学] K835.46[历史地理—历史学]