静脉注射胺碘酮治疗心力衰竭伴快速性心房颤动的疗效观察  

Effect observation of intravenous amiodarone in the treatment of heart failure with rapid atrial fibrillation

作　　者：巩晓宏[1] 常海霞[1] 马锋[1] 谢铎文[1] 刘超峰 

机构地区：[1]西安市中心医院,西安710003 [2]陕西省中医医院,西安710003

出　　处：《西北药学杂志》2012年第5期472-474,共3页Northwest Pharmaceutical Journal

摘　　要：目的观察心力衰竭伴快速性心房颤动患者静脉注射胺碘酮转复或控制心室率治疗心力衰竭的疗效,包括心房颤动的转复率、转复时间、心室率的控制、不良反应及安全性。方法心力衰竭伴快速性心房颤动患者48例,胺碘酮150mg加50g.L-1葡萄糖注射液20mL静脉注射,患者30min后房颤未转复即再应用1次,继以0.5～1mg.min-1维持静滴48h,观察用药后1,2,6,12,24和48h转复率、心室率、心力衰竭症状的缓解及不良反应。结果胺碘酮可快速有效使快速房颤转复为窦性心律,控制心室率,纠正心力衰竭,且无严重不良反应发生。结论心力衰竭伴快速性心房纤颤患者静脉注射胺碘酮治疗安全有效,尤其适用于合并器质性心脏病患者。Objective To Evaluate the effect of intravenous amiodarone for the treatment of heart failure with rapid atrial fibrillation, including the recovery rate of atrial fibrillation,cardioversion rate control,the time of cardioversion,ventricular rate control and its security. Methods 48 cases with heart failure and rapid atrial fibrillation patients were given amiodarone 150 mg plus 50 g · L^-1 glucose solution 20 mL intravenous injection. 30 min after injection if no effect observed, the drug was used again, followed by 0.5-1 mg· min^-1 drops for 48 h. 1,2,6,12,24 and 48 h after cardioversion recovery the adverse reactions were observed. Results Ami-odarone can quickly and effectively make rapid atrial fibrillation cardioversion to sinus rhythm,and no serious adverse reaction was observed. Conclusions Intravenous amiodarone in the treatment of heart failure with rapid atrial fibrillation is safe and effective, especially suitable for the merger of structural heart disease.

关 键 词：胺碘酮 心力衰竭 心房颤动 

分 类 号：R972[医药卫生—药品]