不同组分、不同纯度中药复方多糖对小鼠免疫活性影响的研究  

Research on Chinese Medicinal Compound Polysaccharide's Influence on Mice Immunocompetence with Different Components and Different Purities

作　　者：李赞阳[1] 刘红[2] 罗燕[1] 邵永斌[1] 谷新利[1] 

机构地区：[1]石河子大学动物科技学院,新疆石河子832003 [2]石河子大学化学化工学院,新疆石河子832003

出　　处：《中国畜牧兽医》2012年第9期181-184,共4页China Animal Husbandry & Veterinary Medicine

基　　金：国家自然科学基金项目(30960291)

摘　　要：试验旨在观察不同组分、不同纯度中药复方多糖对小鼠免疫活性的影响。用环磷酰胺作免疫抑制剂建立免疫功能低下动物模型,测定了小鼠腹腔巨噬细胞吞噬功能和免疫器官脏器指数。结果表明,多糖组分A2和中间纯度的多糖B2能够显著提高正常小鼠和免疫抑制小鼠腹腔巨噬细胞的吞噬率、提高胸腺指数和脾脏指数,能够使环磷酰胺造成的免疫抑制逆转至正常水平,因此,具有合适分子质量的多糖组分和合适纯度的多糖能显著增强小鼠的免疫功能。This experiment aims to investigate Chinese medicinal compound polysaccharide＇s influence on mice immunocompetence with different components and different purities.Cyclophosphamide is used as immunity-inhibition agent to build low immunity animal pattern,which leads to the determination of peritoneal macrophage＇s phagocytosis in mice and of organic index of immunity organs.The result shows that polysaccharide component A2 and polysaccharide B2 with average purity can dramatically improve peritoneal macrophage＇s phagocytosis in the group of normal mice and in the immunity-inhibition mice group.These two polysaccharides can also enhance thymus index and spleen index and can reverse immunity inhibition caused by cyclophosphamide to normal level.Therefore it is sound to say that polysaccharide components with appropriate molecular weights and polysaccharide with appropriate purity can greatly improve mice＇s immunity.

关 键 词：不同组分多糖 不同纯度多糖 免疫抑制模型 免疫活性 

分 类 号：S853.7[农业科学—临床兽医学]