丙烯腈作业工人尿硫氰酸盐水平及健康效应  

Urinary Thiocyanate Levels and Health Effects in Workers Exposed to Acrylonitrile

作　　者：李环[1] 郑扬[1] 艾丽莎[1] 

机构地区：[1]盘锦市疾病预防控制中心体检科,辽宁盘锦124010

出　　处：《环境与职业医学》2012年第9期561-562,共2页Journal of Environmental and Occupational Medicine

摘　　要：[目的]调查接触低水平丙烯腈作业工人的尿硫氰酸盐浓度及健康效应,探讨其是否可作为低水平丙烯腈暴露的接触指标。[方法]选取某化工企业接触丙烯腈工人315名作为研究对象,进行常规职业健康检查,并采用吡啶-巴比妥酸比色法测定尿硫氰酸盐浓度。[结果]丙烯腈作业工人尿硫氰酸盐浓度呈正偏态分布,中位数为4.95mg/L,四分位间距为4.84mg/L。尿硫氰酸盐浓度与吸烟、饮酒及其他健康效应均未显示出统计学关联。[结论]尿硫氰酸盐含量不能作为低水平丙烯腈暴露的接触指标。[ Objective ] To determine the levels and health effects of urinary thiocyanate （USCN） in workers exposed to low-level acrylonitrile, and to discuss if USCN levels can be used as an indicator of low-level acrylonitrile exposure. [ Methods ] A total of 315 workers from a chemical factory located in Panjin city were recruited as study subjects and received occupational health examination. The USCN levels were determined by pyrideine-barbituric acid spectrophotometry. [ Results ] The distribution of USCN levels was positively skewed, its median was 4.95 mg/L and the inter-quartile range was 4.84 mg/L. No significant associations of USCN levels were observed with alcohol consumption, cigarette smoking, and other health parameters. [ Conclusion ] Thiocyanate level in random urine samples is not capable of serving as a biomarker of low-level acrylonitrile exposure.

关 键 词：丙烯腈 尿硫氰酸盐 尿样 健康效应 

分 类 号：R135.1[医药卫生—劳动卫生]