南刘寄奴中的一个新1,10-裂环愈创木烷型倍半萜(英文)  

A new 1, 10-secoguaianolide from the aerial parts of Artemisia anomala

作　　者：昝珂[1] 陈筱清[2] 屠鹏飞[1] 

机构地区：[1]北京大学药学院天然药物及仿生药物国家重点实验室,北京100191 [2]首都医科大学中医药学院,北京100069

出　　处：《中国天然药物》2012年第5期358-362,共5页

基　　金：supported by the National Natural Science Foundation of China (No. 30973629);China Postdoctoral Science Foundation (No. 20110490251);Foundation of State Key Laboratory of Natural and Biomimetic Drugs in Peking University (No. K20120213);Capital TCM & Nursing Foundation ( No.11ZYH08)~~

摘　　要：目的:研究南刘寄奴中化学成分。方法:采用硅胶和 ODS 等柱层析分离手段以及半制备高效液相, 运用 NMR、MS 以及理化性质鉴定化合物的结构。结果:从南刘寄奴中分离得到 8 个化合物, 其结构鉴定为 3β-ethoxytanapartholide (1), ((4S*,5S*)-dihydro-5-[(1R*, 2S*)-2-hydroxy-2-methyl-5-oxo-3-cyclopenten-1-yl]-3-methylene-4-(3-oxobutyl)-2(3H)-furanone) (2), ligucy-peronol (3), cyperusol C (4), santamarin (5), 1α, 2α, 3α, 4α, 10α-pentahydroxyguaia-11(13)-ene-12, 6α-olide (6), balanophonin (7),methyl 3-(2’-hydroxy-4’-methoxyphenyl) propanoate (8)。结论:化合物 1 是新人工产物, 化合物 4 和 8 为首次从蒿属中分离得到, 化合物 2–3, 5–7 为首次从该植物中分离得到。AIM： To study chemical constituents of the aerial parts of Artemisia anomala （Asteraceae）. METHODS： The constituents were isolated with silica gel, ODS column chromatography and semi-preparative HPLC, and their structures were elucidated on the basis of physical characteristics and spectral data. RESULTS： Eight compounds were obtained, and their structures were identified as 3,8-ethoxytanapartholide （1）, （4S＊, 5S＊）-dihydro-5-[（1R＊, 2S＊）-2-hydroxy-2-methyl-5-oxo-3-cyclopenten-1-yl]-3-methylene-4-（3-oxobutyl）- 2（3H）-furanone （2）, ligucyperonol （3）, cyperusol C （4）, santamarin （5）, la, 2a, 3a, 4a, 10a -pentahydroxyguala-11（13）-ene-12, 6a-olide （6）, balanophonin （7）, methyl 3-（2＇-hydroxy-4＇-methoxyphenyl） propanoate （8）. CONCLUSION： Compound 1 was a new artifact, 4 and 8 were isolated from the genus Artemisia for the first time, and compounds 2-3, 5-7 were isolated from this plant for the first time.

关 键 词：南刘寄奴 蒿属 化学成分 1 10-裂环愈创木烷型倍半萜 

分 类 号：R284.1[医药卫生—中药学]