绝经后妇女骨质疏松症与心血管病危险因素的相关性研究  

Correlation of Osteoporosis and Cardiovascular Disease Risk Factors in Postmenopausal Women

作　　者：黄卫民[1,2] 孙健玲[3] 李小鹰[4] 王崇禹[3] 师树田[3] 王娟[3] 姜阳[3] 李远征[3] 

机构地区：[1]新疆医科大学第六附属医院脊柱外科,新疆乌鲁木齐市830002 [2]中南大学湘雅医院 [3]航空总医院心内科 [4]解放军总医院老年心内科

出　　处：《实用心脑肺血管病杂志》2012年第9期1442-1444,1447,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨绝经后妇女骨密度与冠心病危险因素的相关性研究。方法选取2007年10月—2011年10月航空总医院心内科门诊及住院的绝经后妇女460例,分为骨质疏松组和非骨质疏松组,记录其存在的心血管病危险因素。结果骨质疏松组中,吸烟、高血脂、糖尿病、冠心病所占的比例高于非骨质疏松组,两组比较差异有统计学意义(P<0.05)。多因素logistic回归分析显示,糖尿病,高脂血症是绝经后妇女骨质疏松患者的主要危险因素。雌激素水平与绝经后妇女骨密度呈负相关,绝经后妇女体内雌激素水平明显下降。结论老年人骨质疏松是一个全身性疾病,与高脂血症等心血管疾病的危险因素密切相关,治疗时应采取系统全身性措施,绝经后妇女骨质疏松患者更应采取积极的预防和治疗措施。Objective To study the correlation of osteoporosis and cardiovascular disease risk factors in postmenopausal women.Methods Four hundred and sixty postmenopausal women who admitted to our department from October 2007 to October 2011 were divided into osteoporosis group and non-osteoporosis group.Their cardiovascular disease risk factors were recorded.Results The proportion of smoking,hyperlipidemia,diabetic mellitus（DM）,and coronary heart diseases were significantly higher in osteoporosis group than in non-osteoporosis group（P〈0.05）.Multivariate unconditional logistic regression analysis showed that DM and heperlipidemia were the major risk factors in postmenopausal women of the osteoporosis patients.Estrogen level was negatively correlated with the bone mineral density in postmenopausal women.The level of estrogen decreased significantly in postmenopausal women.Conclusion Osteoporosis in postmenopausal patients is a systematic disease which is closely correlated with cardiovascular disease risk factors such as hyperlipidemia and should be treated with systematic measures.

关 键 词：骨质疏松 心血管疾病 危险因素 

分 类 号：R681.4[医药卫生—骨科学] R54[医药卫生—外科学]