视、听感觉刺激双模增进作用研究  

Bi-modal enhancement effect from combination of visual and auditory stimulus

作　　者：王悟夷[1] 谢小波[2] 崔红岩[1] 胡理[1] 安兴伟[1] 綦宏志[1] 明东[1] 万柏坤[1] 徐圣普[1] 胡勇[1] 

机构地区：[1]天津,中国医学科学院北京协和医学院生物医学工程研究所,300192 [2]天津大学精密仪器与光电子工程学院,300072

出　　处：《国际生物医学工程杂志》2012年第4期213-216,219,I0003,共6页International Journal of Biomedical Engineering

基　　金：中央级公益性科研院所科研业务专项资助项目;北京协和医学院协和青年科研基金项目;天津市应用基础与前沿技术研究计划青年科学基金项目（12JCQNJC09500）;天津市科技支撑计划重点项目（11ZCKFSY01600） 300072天津大学精密仪器与光电子工程学院王悟夷、安兴伟、綦宏志、明东、万柏坤

摘　　要：目的研究了视（V）、听（A）单模靶刺激与视听双模联合靶刺激（VA）条件下大脑认知作用的差异，进而讨论了双模增进作用的神经机制。方法采用64道脑电（EEG）信号采集系统，记录了14个被试者在视觉、听觉和视听联合靶刺激条件下的脑诱发电位和行为学数据。检测了单模与双模间行为学f反应时间（RT）与错误率（ER）]和事件相关电位（ERPs）（P2峰值和峰值潜伏期，P3峰值和峰值潜伏期）结果的差异；分析了行为学与ERPs数据间的相关性。结果结果显示RT、ER和P3峰值潜伏期在单模与双模间的差异具有统计学意义；P3峰值潜伏期与行为学数据特别是反应时间有显著性相关。结论通过对比视听双模靶刺激和视、听单模靶刺激的行为学和ERPs结果，提示相对视、听单模靶刺激，视听双模靶刺激不仅在早期ERP成份（P1和N1）而且在晚期ERP成分（P2和P3），都表现出优越的感觉信号神经处理机制。Objective To investigate the cognitive difference between uni-modal （V, A） and bi-modal （VA） target stimuli from both vision and audition, and then to study the neural mechanisms of bi-modal enhancement. Methods This experiment adopted a speeded target stimuli detection task, both behavioral and electroencephalographic responses to uni-modal and bi-modal target stimuli which were combined from visual and auditory target stimuli, were recorded from 14 normal subjects using a 64-channel EEG NeuroScan system. The differences of cognitive between uni-modal and bi-modal stimulus were tested from both behavioral （reaction time （RT） and error rate （ER）） and event-related potentials （ERPs） （P2 latency and amplitude, P3 latency and amplitude） data, and the correlation between behavioral and ERPs results were analyzed. Results As a result, the RT, ER and P3 latency has significant difference between uni-modal and bi-modal target stimuli. In addition, there were significant correlation between behavioral data and P3 latency, especially from the RT and P3 latency. Conclusion By comparing the difference between uni-modal and bi-modal from both behavioral and ERPs results, we could reached the conclusion that the neural mechanism of bi-modal target detection was predominant over that of vision and audition uni-modal target detection, the enhancement take place not only involved in early ERP components （such as P1 and N1）, but engaged at the late ERP components （such as P~ and P3）.

关 键 词：行为学 事件相关电位 视觉 听觉 双模增进 

分 类 号：R338.3[医药卫生—人体生理学]