西沙必利联合盐酸帕罗西汀治疗功能性消化不良60例临床观察  

Treatment of functional dyspepsia by Cisapride combined with paroxetine hydrochloride

作　　者：李健[1] 张瑞乐 

机构地区：[1]河北省石家庄市第二医院药剂科,河北石家庄050051 [2]河北省石家庄市第二医院消化内科,河北石家庄050051

出　　处：《河北中医》2012年第9期1432-1434,共3页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的观察西沙必利联合盐酸帕罗西汀治疗功能性消化不良(FD)的临床效果。方法将120例FD患者随机分为2组,治疗组60例予西沙必利片联合盐酸帕罗西汀片治疗,对照组60例予氯波必利片联合氟哌噻吨美利曲辛片治疗。2组均8周为1个疗程,1个疗程后采用汉密尔顿焦虑量表(HAMA)及汉密尔顿抑郁量表(HAMD)评价2组治疗前后心理变化情况,统计临床疗效。结果治疗组总有效率81.7%,对照组总有效率56.7%,2组总有效率比较差异有统计学意义(P<0.05),治疗组临床疗效优于对照组。2治疗后HAMD、HAMA评分与本组治疗前比较均明显下降(P<0.05),且治疗组治疗后低于对照组治疗后(P<0.05)。2组均未发生不良反应。结论西沙必利联合盐酸帕罗西汀治疗FD可改善患者焦虑状态,提高对FD的治疗效果。Objective To clinical effect of Cisapride combined with paroxetine hydrochloride on functional dyspepsia（FD）.Methods 120 cases of FD were randomly divided into two groups.Treatment group（n=60） received combination of Cisapride tablets and paroxetine hydrochloride tablets.Control group（n=60） received combination of Clebopride tablets and flupenthixol melitracen tablets.The therapeutic course was eight weeks in two groups.Psychological change and clinical effect were evaluated by HAMA score and HAMD score.Results The total effective rate in treatment group（81.7%） was higher than that in control group（56.7%,P〈0.01）.HAMA score and HAMD score after treatment were decreased as compared with those before treatment in two groups（P〈0.05）.Those in treatment group were lower than those in control group（P〈0.05）.No adverse reactions occurred in the 2 groups.Conclusion Cisapride combined with paroxetine hydrochloride has a good effect on functional dyspepsia.

关 键 词：消化不良 西沙必利 帕罗西汀 抗抑郁药 

分 类 号：R975[医药卫生—药品] R333.5[医药卫生—药学]