针刺任督脉对脑缺血MSCs移植后促转分化为神经元作用机制的研究思路  

Thinkings on Mechanisms of Conception and Governor Vessel Acupuncture Underlying MSC Transformation and Differentiation into Neurons after Transplantation for Cerebral Ischemia

作　　者：杨卓欣[1] 陈鹏典[2] 于海波[3] 罗文舒[3] 皮敏[3] 吴永刚[3] 彭君华[3] 刘永锋[3] 张少芸[3] 缑燕华[3] 洪媛媛[3] 

机构地区：[1]深圳市妇幼保健院,广东深圳518028 [2]广州中医药大学 [3]广州中医药大学附属深圳市中医院针灸科,广东深圳518033

出　　处：《辽宁中医杂志》2012年第9期1663-1666,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81072877)

摘　　要：间充质干细胞(MSCs)体外移植为临床治疗脑缺血提供前沿的思路和诱人的前景。然而,MSCs在体移植时,其神经元分化率较低。寻找促进MSCs转化为神经元的方法对未来其临床应用和疗效意义重大。前期研究表明,针刺任督脉穴位对脑缺血后神经再生具有积极效应,提示针刺任督脉与MSCs移植联用可能起到促进其转分化为神经元的作用。针刺任督脉有可能通过促进MSCs定殖及移植后向神经元分化和宿主细胞分泌功能、上调损伤区微血管密度、抑制细胞凋亡等,从而起到促进其转分化为神经元的作用。上述思路为中西医结合治疗脑缺血提供新的线索。Mesenchymal stem cells （MSCs）transplantation provides the forward thinkings and attractive prospects for treatment of cerebral ischemia, but the transformation rate into neurons after the transplantation is rather low. Hence,it＇s of significance to explore the effective methods for promoting the transformation rate. The previous studies indicated that conception and governor vessels ac, upuncture has positive effects for nerve regeneration after cerebral ischemia. Accordingly,acupuncture plus MSCs transplantation can promote the MSCs transformation rate by improving the MSC proliferation and differentiation into neurons, up-regulating neurotrophic factor expressions, enhancing angiogenesis and inhibiting cellular apoptosis hence accelerate its transformation, which may provide a novel clue for treatment of cerebral ischemia by joint administration of integrative traditional and western medicine.

关 键 词：间充质干细胞移植 脑缺血 任督脉 针刺 

分 类 号：R2-03[医药卫生—中医学]