Synthesis of Polysubstituted 1,4-Dihydropyridines via Four-component Reactions of Arylamine,Acetylenedicarboxylate, Aromatic Aldehyde and Ethyl Acetoacetate  

作　　者：WU Ping XIA Er-yan SUN Jing YAN Chao-guo 

机构地区：[1]Department of Biochemical Engineering,Yangzhou Polytechnic University,Yangzhou 225000,P.R.China [2]College of Chemistry&Chemical Engineering,Yangzhou University,Yangzhou 225002,P..R.China

出　　处：《Chemical Research in Chinese Universities》2012年第4期652-655,共4页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.20972132);the Fund of Key Laboratory of Environmental Resource and Material,Jiangsu Province,China

摘　　要：An efficient synthetic protocol for the 1,4-diaryl-1,4-dihydropyridines was developed via the domino four-component reaction of arylamine,acetylenedicarboxylate,aromatic aldehyde and ethyl acetoacetate.The reaction mechanism involves the formation of β-enamino ester and its sequential Michael addition to arylidene acetoacetate.An efficient synthetic protocol for the 1,4-diaryl-1,4-dihydropyridines was developed via the domino four-component reaction of arylamine,acetylenedicarboxylate,aromatic aldehyde and ethyl acetoacetate.The reaction mechanism involves the formation of β-enamino ester and its sequential Michael addition to arylidene acetoacetate.

关 键 词：1 4-Dihydropyridine β-Enamino ester Domino reaction Four-component reaction 

分 类 号：O625.631[理学—有机化学] TQ655[理学—化学]