消栓通胶囊抗脑缺血作用的实验研究  

Experiment Study of Compound Xiaoshuantong Capsule Against Cerebral Ischemia

作　　者：谢艳华[1] 贺中民[1] 王四旺[1] 杨倩[1] 

机构地区：[1]中国人民解放军第四军医大学药学系药物研究所,陕西西安710032

出　　处：《现代生物医学进展》2012年第24期4627-4632,共6页Progress in Modern Biomedicine

摘　　要：目的:观察消栓通胶囊对双侧颈总动脉结扎的大鼠脑缺血的保护作用;对小鼠断头后存活时间的影响。方法:采用结扎大鼠双侧颈总动脉以造成脑缺血模型,观察消栓通胶囊的药理作用。结果:①a.消栓通胶囊对双侧颈总动脉结扎大鼠脑含水量及脑指数有显著影响,消栓通胶囊三个剂量组(0.20 g/kg、0.40 g/kg、0.80 g/kg),脑含水量明显减少,与模型组有显著差异(P<0.05或P<0.01)。b.组织病理学检查表明消栓通胶囊组的脑组织神经细胞浓缩及深染较脑缺血模型组明显减轻;神经胶质细胞肿胀及间质疏松程度均明显轻于模型组。②消栓通胶囊三个剂量组(0.20 g/kg、0.40 g/kg、0.80 g/kg)均能明显降低全血粘度值,与模型组比较有明显差异(P<0.05或P<0.01);③消栓通胶囊三个剂量组(0.25 g/kg、0.50 g/kg、1.00 g/kg)给药14d,与正常组比较可延长小鼠断头喘气的时间(P<0.05或P<0.01)。结论:消栓通胶囊对大鼠结扎双侧颈总动脉所致脑缺血损伤具有明显的保护作用。Objective： Observing the protection of Xiaoshuantong-capsule to the rats whose both ligated common carotid artery re- sult to cerebral ischemia; survival time of the decapitated mouse. Methods： Observing the pharmacologic action of Xiaoshuantong -cap- sule ischemia. Results： （1） a. The Xiaoshuantong -capsule has a significant impact on cerebral water content and the cerebral index the both ligated common carotid artery rats, three dose groups of Xiaoshuantong -capsule （0.20 g/kg, 0.40 g/kg, 0.80 g/kg） as compared to model show to cerebral water content decrease （P〈0.05 or P〈0.01 ）.b. The histopathology inspection manifest that the concentration and anachromasis of the nerve cells of the cerebral tissue have obviously lessen compared with the group of cerebral ischemia; both the neu- roepithelial cellular swelling and the mesenchymal rarefaction have obviously lessening. （2）Three dose groups of Xiaoshuantong -capsule （0.20 g/kg, 0.40 g/kg, 0.80 g/kg） as compared to model show that they could reduce the blood viscosity （P〈0.05 or P〈0.01 ）. （3）Dosaging after 14 days, three dose groups of Xiaoshuantong -capsule （0.25 g/kg, 0.50 g/kg, 1.00 gJkg） as compared to normal group have pro- longed the gasp time of decapitated mouse （P〈0.05 or P〈0.01 ）. Conclusion： Xiaoshuantong -capsule has significant protection on the cerebral ischemia that were cerebral ischemia by ligated both sides of carotid artery.

关 键 词：消栓通胶囊 脑缺血 中风 大鼠 小鼠 

分 类 号：Q95-3[生物学—动物学] R541[医药卫生—心血管疾病]