核周型抗中性粒细胞胞浆抗体在狼疮性肾炎中的临床意义  

Clinical Significance of Serum Perinuclear Antineutrophil Cytoplasmic Antibodies in Lupus Nephritis

作　　者：陈雅硕[1] 李博[1] 余凤嫦[1] 叶志中[1] 黄进贤[1] 孔卫红[1] 何伟珍[1] 

机构地区：[1]深圳市第四人民医院香蜜湖风湿病分院广东医学院深圳风湿病研究所,广东深圳518040

出　　处：《现代生物医学进展》2012年第24期4670-4672,4760,共4页Progress in Modern Biomedicine

基　　金：国家"十一.五"科技支撑计划项目(2008BAI59B02);深圳医学重点学科建设资助项目(2005C10)

摘　　要：目的:探讨核周型抗中性粒细胞胞浆抗体(P-ANCA)在狼疮性肾炎(LN)中的临床意义。方法:应用酶联免疫吸附分析(ELISA)的方法,检测92例LN患者血清中的P-ANCA及其他自身抗体的水平,并进一步分析P-ANCA与LN的临床表现以及辅助检查结果之间的关系。结果:P-ANCA在LN中的阳性率是21.8%(20/92),P-ANCA阳性组LN患者合并颧部红斑、皮肤血管炎、贫血以及补体C3偏低的频率均显著高于P-ANCA阴性组LN患者(P<0.05)。结论:P-ANCA在LN中的阳性率为21.8%,且P-ANCA与SLE特定的临床表现相关,提示P-ANCA可能参与了LN的发病过程。Objective： To elucidate the clinical significance of serum perinuclear antineutrophil cytoplasmic antibodies （P-ANCA） in patients with lupus nephritis （LN）. Methods： P-ANCA was detected in serum samples obtained from 92 patients with LN by emzyme-linked immunosorbent assay （ELISA）. The relationship between P-ANCA and clinical manifestations and other autoantibodies were analyzed. Results： P-ANCA positive was detected in 21.8 % （20/92） patients. The prevalence of malar rash, cutaneous small vas- culitis, central nervous system involved, anemia and hypocomplementemia were all significantly higher in P-ANCA-positive patients than P-ANCA-negative patients （P〈0.05）. Conclusions： The prevalence of P-ANCA was 21.8 % in LN and its presence was correlated with particular clinical manifestations, indicating that P-ANCA may play a pathogenetic role in LN.

关 键 词：抗中性粒细胞胞浆抗体 狼疮性肾炎 酶联免疫吸附分析 

分 类 号：R593.242[医药卫生—内科学]