学龄儿童行为遗传双生子研究  

Genetics study on behavior problems in school-age twins

作　　者：李玉玲[1] 季成叶[2] 关宏岩[3] 陆舜华[1] 赵曼[1] 栾天抒[1] 

机构地区：[1]内蒙古师范大学生命科学与技术学院,呼和浩特010022 [2]北京大学儿童青少年卫生研究所 [3]首都儿科研究所

出　　处：《中国学校卫生》2012年第9期1033-1034,1037,共3页Chinese Journal of School Health

基　　金：国家自然科学基金项目(30371223);国家自然科学基金项目(30960167)

摘　　要：目的利用双生子人群估计学龄儿童行为指标的遗传度,为降低儿童行为问题的发生提供依据。方法采用Achenbach's儿童行为量表对在呼和浩特市募集的166对6～12岁双生子心理行为问题进行调查。对调查结果进行结构方程模型拟合,估算学龄儿童行为指标的遗传度。结果行为总粗分遗传度为男30.26%,女32.80%;各行为分因子遗传度分别为焦虑/抑郁(男46.79%,女74.99%)、退缩(男56.45%,女78.33%)、思维(男58.95%,女63.25%)、注意力(男79.14%,女40.11%)、社会化问题(男26.13%,女52.09%)、违规行为(男37.09%,女0.00%)、攻击性行为(男84.57%,女50.15%)、其他问题(男75.21%,女70.29%)。注意力和攻击性行为的遗传度存在性别效应,男生的遗传度均明显高于女生。年龄对学龄儿童行为问题的遗传效应无明显影响。结论学龄儿童行为问题受遗传与环境因素的共同影响,注意力和攻击性行为的遗传效应可能存在性别作用。Objective To estimate the heritability of behavior problems in school-age children by twins data. Methods The behavior problems were assessed in a total of 166 twin pairs aged 6 - 12 years in Huhhot with the Child Behavior Checklist （ CBCL}. Structural equation modeling was performed to evaluate the heritability of behavior problems in school-age children. Re- suits For behavior problems of school-age children, the genetic factors { heritability） explained about 30.26% in boys and 32.80% in girls of the total variance. The heritabilities of anxiety/depression, withdrawn, thought problems, attention problems, social problems, delinquent problems, aggressive behavior and other problems were 46.79%, 56.45% , 58.59%, 79. 14%, 26.13%, 37.09%, 84.57% and 75.21% in the boys and 74.99%, 78.33%, 63.25%, 40.11%, 52.09%, 0.00%, 50.51% and 70.29% in the girls respectively. The gender effect existed in the heritabilities of attention problems and aggressive behavior, and the male~ heritabilities of them were higher than those of females. The genetic and environmental effects of the behavior problems of school-age children were not influenced by the age. Conclusion The behavior problems of school-age children are influ- enced by genetic and environmental factors. There are gender effects on the heritabilities of attention problems and aggressive behavior.

关 键 词：行为 遗传 双生子研究 精神卫生 儿童 

分 类 号：R179[医药卫生—妇幼卫生保健] R395.6[医药卫生—公共卫生与预防医学]