石油作业女性染色单体交换与习惯性流产关系研究  

Study on the relationship between sister chromatid exchange and habitual abortion among the women in the petroleum operations

作　　者：慕明涛[1] 霍满鹏[1] 蒲力群[1] 张静[1] 刘俊俊[1] 

机构地区：[1]延安大学医学院医学遗传学与细胞生物学教研室,陕西延安716000

出　　处：《中国妇幼保健》2012年第28期4426-4427,共2页Maternal and Child Health Care of China

基　　金：延安大学科研计划项目

摘　　要：目的:分析石油作业女性外周血淋巴细胞姐妹染色单体互换(SCE)对习惯性流产的影响。方法:随机选择习惯性流产的石油作业女性26人为观察组和正常的育龄女性18人为对照组,检测其外周血淋巴细胞姐妹染色单体互换,记数SCE发生率。结果:观察组的外周血淋巴细胞SCE发生率为8.66±0.61明显高于对照组,差异有统计学意义(P<0.05)。结论:SCE的发生可作为石油作业习惯性流产女性染色体结构稳定性的检测指标。石油作业环境中的某些有害物质对女性DNA损伤有一定的影响。Objective： To analyze the effect of sister chromatid exchange （SCE） in lymphocytes in peripheral blood of the women in the petroleum operations on habitual abortion. Methods： Twenty -six women in the petroleum operations with habitual abortion and 18 normal women at childbearing age were selected randomly as observation group and control group respectively. SCE in lymphocytes in periph- eral blood was detected, and the incidence was recorded. Results： The incidence of SCE in lymphocytes in peripheral blood of observation group was （8.66 ± 0. 61 ）, which was significantly higher than that in control group （P 〈 0. 05） . Conclusion： The occurrence of SCE can be used as a index to detect the structural stability of chromosomes in women with habitual abortion; some harmful substances in the environment in petroleum operations have a certain impact on injury of female DNA.

关 键 词：习惯性流产 姐妹染色单体互换 DNA损伤 

分 类 号：R714.21[医药卫生—妇产科学]