肺炎克雷伯菌耐药表型的分布及其耐药性分析  

Phenotypes and drug resistance of clinical isolates of Klebsiella pneumoniae

作　　者：刘素玲[1] 侯铁英[1] 何启勇[1] 张莉滟[1] 陈柳勤[1] 

机构地区：[1]广东省医学科学院广东省人民医院临床微生物科,广东广州510080

出　　处：《中华医院感染学杂志》2012年第17期3694-3696,共3页Chinese Journal of Nosocomiology

摘　　要：目的调查肺炎克雷伯菌(KPN)临床株产不同β-内酰胺酶株分布情况、表型特征及耐药现状,指导临床合理使用抗菌药物。方法采用VITEK-2Compact对肺炎克雷伯菌进行鉴定和药敏试验。结果 291株KPN表型主要分为3类:产ESBLs类、产获得性青霉素酶类、野生型;其中产ESBLs株占48.1%;产获得性青霉素酶类占35.1%;野生株占14.4%;此外产碳青霉烯酶菌株7株,占2.4%,产酶总阳性率为85.6%;产ESBLs菌株对多数抗菌药物的耐药性明显高于非产ESBLs菌株。结论应高度重视对KPN产酶株的监控,合理使用抗菌药物,控制耐药株的产生与扩散。OBJECTIVE To evaluate the distribution,phenotypes and the drug resistance profiles of different kinds of β-lactamase-producing Klebsiella pneumoniae isolated from clinic.METHODS VITEK 2 compact was used to identify K.pneumoniae isolates,antimicrobial susceptibility testing was performed.RESULTS The phenotypes of 291 isolates of K.pneumoniae mainly presented as the following three categories： ESBLs-producing strains（48.1%）,acquired-penicillinase-producing isolates（35.1%）,and wild type isolates（14.4%）;there were 7 strains of carbapenemase-producing isolates,accounting for 2.4%;the total β-lactamases-producing rate was 85.6%;the drug resistant rates of ESBLs-producing isolates were significantly higher than those of non-ESBLs-producing isolates.CONCLUSION We should attach great importance to the monitoring of the enzyme-producing K.pneumoniae isolates.It is necessary to reasonably use antibiotics so as to control the emergence and the spread of drug resistant strains.

关 键 词：肺炎克雷伯菌 耐药表型 超广谱Β-内酰胺酶 

分 类 号：R378.996[医药卫生—病原生物学]