2006-2010年重症病区铜绿假单胞菌耐药性监测研究  

Monitoring of drug resistance of Pseudomonas aeruginosa in severe wards in 2006-2010

作　　者：马玲[1] 叶扬[1] 李俊洁[1] 

机构地区：[1]新疆昌吉州人民医院检验科,新疆昌吉州831100

出　　处：《中华医院感染学杂志》2012年第17期3852-3854,共3页Chinese Journal of Nosocomiology

摘　　要：目的分析了解重症病区铜绿假单胞菌(PAE)医院感染的现状及耐药性,为临床合理选用抗菌药物提供科学依据。方法采用ATB系统鉴定菌株和药敏试验。结果 2006-2010年共检出铜绿假单胞菌295株,临床重症与非重症病区铜绿假单胞菌的检出率分别为61.4%和38.6%;重症病区以下呼吸道分泌物标本最高占47.5%,非重症病区以痰液标本最高占65.8%;PAE对抗菌药物的耐药率以多黏菌素E的5.4%和阿米卡星的5.8%最低、氨苄西林/舒巴坦的97.9%和磺胺甲噁唑/甲氧苄啶的97.3%最高;对抗菌药物的耐药率重症病区明显高于非重症病区,差异有统计学意义(P<0.05)。结论合理使用抗菌药物,加强医院感染的监测、预防与控制,以减少耐药菌株的产生。OBJECTIVE To analyze the current status of Pseudomonas aeruginosa infections in severe wards and the drug resistance so as to provide scientific bases for reasonable use of antibiotics.METHODS ATB system was adopted for the identification of bacteria and the drug susceptibility testing.RESULTS A total of 295 strains of P.aeruginosa were detected in 2006-2010,the detection rates of P.aeruginosa in clinical severe wards and non-severe wards were 61.3% and 38.7%,respectively;the secretions from the lower respiratory tract was the main specimen sources in severe wards,accounting for 47.5%,and the sputum was the major specimen sources in non-severe wards,accounting for 65.8%,the drug resistance rates of P.aeruginosa to polymycin E（5.4%） and amikacin（5.8%） were the lowest,the drug resistance rates to ampicillin/sulbactam（97.9%） and sulfamethoxazole/trimethoprim（97.3%） were the highest;the drug resistance rate of P.aeruginosa in severe wards was significantly higher than that in non-severe wards,with statistical significance（P〈0.05）.CONCLUSION It is necessary to reasonably use antibiotics and strengthen the surveillance,prevention and control of nosocomial infections.

关 键 词：铜绿假单胞菌 重症病区 耐药性 抗菌药物 医院感染 

分 类 号：R378.991[医药卫生—病原生物学]