DAZ基因家族生物学功能的研究进展  

Advance in biological functions of the DAZ gene family

作　　者：王正荣[1] 薄新文[1] 赵文娟[1] 

机构地区：[1]新疆农垦科学院畜牧兽医研究所绵羊重点繁育实验室,新疆石河子832000

出　　处：《黑龙江畜牧兽医》2012年第9期24-27,共4页Heilongjiang Animal Science And veterinary Medicine

基　　金：“973”国家重点基础研究发展计划项目(2006CB708512);兵团杰出青年创新资金项目(2011CD005);兰州兽医研究所2011年度开放基金项目(SKLVEB2011KFKT008)

摘　　要：雄性不育是医学界关注的重要问题之一,其病因多种多样,其中精子质量和无精子症基因(DAZ)是2个重要因素。后者即DAZ基因家族,包括DAZ、DAZL和BOULE基因,是精子生成的重要调控因子。DAZ基因家族成员只在生殖细胞中表达,并且它们的蛋白产物均含有一个高度保守的RNA结合序列。DAZ基因家族的无义突变影响雄性或雌性的生殖,DAZ和DAZL基因在生殖细胞的整个生命过程中都有表达,是原始生殖细胞发育以及生殖细胞分化、成熟所必需的;BOULE基因仅在减数分裂期表达,具有特定的生物学功能。DAZ蛋白在体内和体外都可与RNA结合,并有可能参与了mRNA转录后的表达调控,文章仅就近年来DAZ基因家族生物学功能的研究状况作一综述。Male infertility is one of important problems of concern to the medical profession, and its causes are varied, including sperm quality and the deleted in azoospermia （DAZ） gene. DAZ gene family consists of three genes ： BOULE, DAZ - Like （DAZL） and DAZ. The members of the DAZ gene family are expressed only in germ cells, and their protein products contain a highly conserved RNA - binding sequence. Non- sense mutations of the DAZ family affect the reproduction of either male or female, or both sexes. DAZ and DAZL are expressed throughout the life course of germ cells and are necessary for the development of primordial germ cells and the differentiation and maturation of the germ ceils. BOULE is expressed in the meiosis stage and has a particular function. The DAZ proteins can be binding RNAs in vitro and in vivo, and may be involved in the regulation of expression after mRNA transcripts. This paper reviews the biological function of DAZ gene family.

关 键 词：DAZ基因家族 雄性不育 生物学功能. 

分 类 号：S813.3[农业科学—畜牧学]