最终结果:Ghrelin可抑制人体胰岛素分泌,这是其临床密切关系吗?  

Final answer: Ghrelin can suppress insulin secretion in humans,but Is It Clinically Relevant?

作　　者：洪珊珊[1] 钱荣立[1] 

机构地区：[1]中国糖尿病杂志编辑部,北京100034

出　　处：《中国糖尿病杂志》2012年第9期719-720,共2页Chinese Journal of Diabetes

摘　　要：Ghrelin是在人体和大鼠胃内发现的28-氨基酸肽,是生长激素促分泌素受体(GHS-R1a)的内源性配体。1999年首次被发现。其作用包括:与GHS-R1a结合,增加脑下垂体分泌生长激素;影响食物摄入和体脂水平;调节细胞增殖和存活、生长和繁殖以及代谢等。最近,Ghrelin是否会对β细胞功能产生作用也成为研究热点之一。这一领域的研究具有重要意义,其可能增加胰岛素分泌从而可能成为治疗T2DM的新途径。Ghrelin is a 28-amino acid peptide initially isolated from rat and human stomachs as an endogenous ligand for the growth hormone secretagogue receptor type la （GHS-Rla） and was discovered in 1999. Ghrelin was known to increase growth hormone release from the pituitary gland by binding to GHS-R1a, which had a role in food intake and body adiposity, and regulated cell proliferation and survival, apoptosis, inflammation, angiogenesis, development and reproduction as well as metabolism. Recently, it has been of great research interest whether ghrelin also has a role in B-cell function or not. This research area is particularly important given its potential to lead to the development of novel strategies to increase insulin secretion for the treatment of type 2 diabetes. Here we translated the essentials of Final answer： Ghrelin can suppress insulin secretion in humans, but is it clinically relevant？

关 键 词：GHRELIN 糖尿病 2型 胰岛素 

分 类 号：R589[医药卫生—内分泌]