固定化脯氨酸及其衍生物用于催化不对称有机合成  

Immobilized Proline and Its Derivatives Employed in the Catalysis of Asymmetric Organic Synthesis

作　　者：侯晨[1] 朱浩[1] 李亦婧[1] 李彦锋[1] 

机构地区：[1]兰州大学化学化工学院、功能有机分子化学国家重点实验室、生物化工及环境技术研究所,兰州730000

出　　处：《化学进展》2012年第9期1729-1741,共13页Progress in Chemistry

基　　金：国家自然科学基金项目(No.21074049);功能有机分子化学国家重点实验室开放基金(SKLAOC-2009-35)资助

摘　　要：脯氨酸及其衍生物作为有机手性催化剂,在不对称有机合成中得到广泛应用。该类催化剂具有结构简单、来源丰富和选择性高等优点,但仍存在催化剂用量大、难以回收以及无法重复利用等不足。近年来,随着固定化技术的发展,固定化脯氨酸及其衍生物受到广泛关注。固定化脯氨酸及其衍生物催化剂可以简化不对称催化中产物的分离过程,实现催化剂的便利回收与循环使用。本文综述了固定化脯氨酸及其衍生物的制备及在催化不对称有机合成(如Aldol反应、Michael加成反应、Mannich反应等)中的研究进展。During the past several years, poline and its derivatives were widely used as a kind of chiral organocatalysts in asymmetric organic synthesis. Due to their simple structure, high efficiency and superior stereoselectivity, poline and its derivatives are considered as one of the most promising chiral organoeatalysts in asymmetric organic synthesis. However, a large amount of catalyst is necessarily used in reactions. The recovery and reuse of the catalysts are also impracticable. Since the immobilization of proline and its derivatives could simplify the separation of the products and facilitate catalyst recovery and reuse, the immobilization of proline and its derivatives and their applications in asymmetric organic synthesis are caused highly concern. A great deal of research focused on the immobilized proline and its derivatives achieved satisfactory achievement in recent years. The preparation of immobilized proline and its derivatives and their applications in asymmetric organic synthesis, such as Aldol reaction, Michael reaction and Mannich reaction, etc. are summarized in this review.

关 键 词：脯氨酸 衍生物 固定化 不对称有机合成 

分 类 号：O621.34[理学—有机化学] O621.251[理学—化学]