不稳定性心绞痛冠脉介入术前FIB、D-二聚体水平对预后预测的意义  

Significance of predicting prognosis about level of fibrinogen,d-dimer in unstable angina before percutaneous coronary intervention

作　　者：孙炎华[1] 靳妮娜[2] 张高星[1] 林如明[1] 赖兆新[1] 谭文峰[1] 彭宇程[1] 任强[1] 高伟栋[1] 赖浚兴[1] 宋岸坚[1] 

机构地区：[1]中山大学附属江门医院心血管内科,广东江门529030 [2]中山大学附属江门医院呼吸内科,广东529030

出　　处：《齐齐哈尔医学院学报》2012年第16期2143-2145,共3页Journal of Qiqihar Medical University

基　　金：江门市科技局项目(2011NO:22)

摘　　要：目的探讨不稳定性心绞痛(UA)患者冠脉介入术前纤维蛋白原(FIB)、D-二聚体水平能否预测UA患者的预后。方法入选行冠脉介入术的90例UA患者为UA组,90例健康体检者为对照组,测定两组患者血浆中FIB、D-二聚体的水平,UA组患者于抽血6个月后进行心血管事件评定,发生心血管事件者定为事件组,其余则为非事件组。结果 UA组患者FIB、D-二聚体的水平较对照组高(P<0.05);与非事件组比较,事件组患者FIB、D-二聚体的水平较高(P<0.05),事件组患者FIB、D-二聚体水平呈正相关(P<0.01),r≈0.76。结论联合检测不稳定性心绞痛患者冠脉介入术前血浆FIB、D-二聚体的水平能预测其预后。Objective To study the level of fibrinogen, d--dimer in unstable angina before percu- taneous coronary intervention whether can predict the prognosis. Methods 90 patients with unstable an- gina whom were treaded by percutaneous coronary intervention were regarded as UA group, 90 healthy peoples were regarded as control group. The levels of plasma FIB, d--dimer were detected in all of them. The patients of unstable angina who occurred cardiovascular events in 6 months were regarded as events group, the rest were non--event group. Results Compared with control group, the level of plas- ma FIB, d--dimer were higher in UA group （P 〈 0.05）. Compared with the non--even group, the level of plasma FIB, d--dimer were higher in the event group （P 〈 0.05）. In the event group, the level of plasma FIB was positively correlated with d--dimer （P 〈 0.01）, r≈0.76. Conclusions To detect the levels of plasma FIB, d--dimer together in unstable angina before percutaneous coronary intervention can predict the prognosis.

关 键 词：不稳定性心绞痛 纤维蛋白原 D-二聚体 预后 

分 类 号：R541.4[医药卫生—心血管疾病]