正交试验设计优化银杏内酯B醇质体的制备工艺  

Optimization technology of preparation for Ginkgolide-B ethosomes by orthogonal design

作　　者：吕立华[1] 吕林华[2] 张玉碧 

机构地区：[1]邵阳医学高等专科学校药学系 [2]中山大学附属第一医院 [3]邵阳市中心医院血液肿瘤科

出　　处：《齐齐哈尔医学院学报》2012年第16期2213-2214,共2页Journal of Qiqihar Medical University

基　　金：湖南省科技计划项目经费资助(项目编号:2011SK3034)

摘　　要：目的通过优选膜材、工艺、处方,制备出透皮吸收优良的醇质体。方法以包封率为考察指标、通过正交设计,考察银杏内酯B醇质体制备过程中磷脂的浓度、乙醇含量、超声时间各因素的影响,确定最佳处方。结果银杏内酯B筛选的最佳处方为磷脂浓度为1.50g/L,醇含量为40%(v/v),超声时间为10min。以优化工艺制得的银杏内酯B醇质体平均包封率为(87.98±1.35)%。结论正交试验优化银杏内酯B醇质体制备工艺经验证,结果稳定,从而确保了质量。Objective To prepare Ginkgolide--B ethosomes with good permeability by optimizing fonnulations preparation technology and formulations. Methods Encapsulating efficiency as index , the effect of phospholipids concentration, ethanol content sonieation time during preparation was studied by orthogonal design. Results The best formulations for Ginkgolide--B ethosomes were 1.5g/L, phospho- lipids concentration, 40% （v/v） ethanol content and 10min sonication time Ginkgolide--B ethosomes preparation according to this formulations was with uniform mean encapsulating efficiency （87.98 ± 1. 35） %. Conclusions The preparation process or orthogonal test has good reproduction and stability to guarantee the effects of the medicine.

关 键 词：正交试验 银杏内酯B 醇质体 经皮给药系统 

分 类 号：R285.5[医药卫生—中药学]