右美托咪定对经尿道前列腺切除术患者寒战发生的预防效果  

Effect of dexmedetomidine on preventing chills during transurethral resection of prostate

作　　者：韩智晓[1] 傅艳妮[1] 梁建军[1] 张昆[1] 赵一凡[1] 

机构地区：[1]中山大学孙逸仙纪念医院麻醉科,广州510120

出　　处：《岭南现代临床外科》2012年第5期277-279,共3页Lingnan Modern Clinics in Surgery

基　　金：广东省科技计划项目(No.2010B060900039)

摘　　要：目的观察右美托咪定对经尿道前列腺切除术患者寒战发生的预防效果。方法 90例择期在腰硬联合麻醉下行经尿道前列腺切除术(TURP)患者,随机等分为3组(n=30):右美托咪定组(D组)、曲马多组(T组)、对照组(C组)。麻醉后分别于10分钟内持续静脉泵注右美托咪定0.5μg/kg、曲马多1mg/kg或等量生理盐水,记录3组患者的平均动脉压(MAP)、心率(HR)、血氧饱和度(SpO2),评估患者术中寒战级别和恶心、呕吐等不良反应。结果 D组寒战发生率低于C组(P<0.05),D、T组寒战发生率无明显差异(P>0.05),D组恶心、呕吐发生率较T组降低(P<0.05),D组血压、心率低于T、C组(P<0.05)。结论 0.5μg/kg右美托咪定可以有效预防经尿道前列腺切除术中寒战,效果与1mg/kg曲马多相当,而恶心、呕吐不良反应少。Objective To observe the effect of dexmedetomidine on preventing shivering of patients undergoing the surgery of transurethral resection of prostate （TURP）. Methods Ninety of ASA I or Ⅱ patients scheduled for selective TURP surgery under combined spinal-epidural anesthesia were equally randomized into dexmedetomidine group （group D）, tramadol group （group T） and saline group （group C）. After spinal anesthesia, patients were pump infused dexmedetomidine at 0.5 μg/kg in Group D, tramadol at 1 mg/kg in Group T or saline in Group C for 10 minutes. MAP, HR, SpO2 were recorded, and shivering was evaluated by Wrench Grades. Rates of nausea and vomiting were calculated as well. Results Shivering grades were lower in group D than in group C and there were no difference between group D and group T. The rates of nausea and vomiting were lower in group D than in group T. MAP,HR of patients were lower in group D than in group T and C. Conclusion Intravenous administration of dexmdetomidine 0.5 μg/kg can prevent shivering of patients during transurethral resection of prostate as well as tramadol 1mg/kg,but with less side effects.

关 键 词：右美托咪定 曲马多 经尿道前列腺切除术 寒战 

分 类 号：R614.2[医药卫生—麻醉学]