Synthesis, Crystal structure and Antioxidant of 3,5-Dihydroxy-N′-(5-bro-2-hydroxybenzylidene)benzohydrazide Hydrate  

作　　者：孙振高 连方 张建伟 孙金龙 郭颖 张宁 刁云鹏 

机构地区：[1]Affiliated Hospital of Shandong University of Traditional Chinese Medicine&Pharmaceuticals [2]Shandong University of Traditional Chinese Medicine&Pharmaceuticals [3]College of Pharmacy,Dalian Medical University

出　　处：《Chinese Journal of Structural Chemistry》2012年第9期1309-1314,共6页结构化学（英文）

基　　金：the National Natural Science Foundation of China (No. 30772601);Shandong province natural funded Projects (No. Q2008C17);Shandong province traditional Chinese medical science and technology development programs (No. 2009-038)

摘　　要：A new compound, 3,5-dihydroxy-N′-（5-bro-2-hydroxybenzylidene）benzohydrazide hydrate, has been synthesized and characterized by single-crystal X-ray diffraction. The title compound crystallizes in a monoclinic system, space group P21/c with a = 14.267（6）, b = 8.079（4）, c = 13.157（6） , β = 108.114（4）, Z = 4, V = 1441.4（11） 3, Dc = 1.701 g/cm3, F（000） = 744.0, μ = 2.878 and S = 1.021. The final R = 0.0457 and wR = 0.1149 for 3500 observed reflections with I 〉 2 （I）. The ability with which the compound scavenges free radicals of ABTS and DPPH, IC50, is 34.13 and 101.6 μM, respectively.A new compound, 3,5-dihydroxy-N′-（5-bro-2-hydroxybenzylidene）benzohydrazide hydrate, has been synthesized and characterized by single-crystal X-ray diffraction. The title compound crystallizes in a monoclinic system, space group P21/c with a = 14.267（6）, b = 8.079（4）, c = 13.157（6） , β = 108.114（4）, Z = 4, V = 1441.4（11） 3, Dc = 1.701 g/cm3, F（000） = 744.0, μ = 2.878 and S = 1.021. The final R = 0.0457 and wR = 0.1149 for 3500 observed reflections with I 〉 2 （I）. The ability with which the compound scavenges free radicals of ABTS and DPPH, IC50, is 34.13 and 101.6 μM, respectively.

关 键 词：Schiff base COMPOUND crystal structure antioxidant activity 

分 类 号：O621.2[理学—有机化学]